Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer

Shigeru Yamada, Makoto Shinoto, Shigeo Yasuda, Hiroshi Imada, Hirotoshi Kato, Tadashi Kamada, Hirohiko Tsujii

Research output: Contribution to journalArticle

10 Citations (Scopus)


Purpose: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Patients and Methods: We conducted a phase I / II dose escalation study of carbon ion radiotherapy. One hundred twelve patients with 117 sites of locally recurrent cancer receiving carbon ion radiotherapy were analyzed. Results: None of 112 patients experienced National Cancer Institute-Common Toxicity Criteria grade 3 to 5 acute reactions. The local control rate in patients treated with 67.2 GyE, 70.4 GyE and 73.6 GyE in the present study was 70%, 89% and 97% at 5 years, respectively. The overall survival rates in patients treated with 73.6 GyE were 72% at 3 years and 40% at 5 years. Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity.

Original languageEnglish
Pages (from-to)1263-1266
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Issue number8
Publication statusPublished - Aug 2009


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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