Cushing’s syndrome and psychosis: A case report and literature review

Yuka Fujii, Yoshito Mizoguchi, Jun Masuoka, Yayoi Matsuda, Tatsuya Abe, Keizo Anzai, Yutaka Kunitake, Hiroshi Tateishi, Takayoshi Inaba, Toru Murakawa, Takahiro A. Kato, Akira Monji

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Abstract

Psychiatric complications of Cushing’s syndrome include irritability, anxiety, depressed mood, and cognitive impairment. Psychosis is a rare manifestation of Cushing’s syndrome; therefore, the literature on the subject is limited and consists mainly of clinical case reports. We report a case of Cushing’s syndrome misdiagnosed as schizophrenia-like psychosis for more than 10 years. Transsphenoidal adenomectomy resulted in amelioration of psychiatric symptoms as well as improvement of cognitive ability. Clinicians should consider the presence of psychiatric symptoms predating the diagnosis of Cushing’s syndrome, especially when these symptoms are persistent and treatment-resistant, as seen in the present case.

Original languageEnglish
Article number18br02279
JournalPrimary Care Companion to the Journal of Clinical Psychiatry
Volume20
Issue number5
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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    Fujii, Y., Mizoguchi, Y., Masuoka, J., Matsuda, Y., Abe, T., Anzai, K., Kunitake, Y., Tateishi, H., Inaba, T., Murakawa, T., Kato, T. A., & Monji, A. (2018). Cushing’s syndrome and psychosis: A case report and literature review. Primary Care Companion to the Journal of Clinical Psychiatry, 20(5), [18br02279]. https://doi.org/10.4088/PCC.18br02279