Cutaneous and lingual papules as a sign of β2 microglobulin-derived amyloidosis in a long-term hemodialysis patient

Takeshi Uenotsuchi, Shinichi Imafuku, Masaharu Nagata, Hiromaro Kiryu, Keisuke Morita, Tetsuya Koga, Masutaka Furue

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Although hemodialysis has permitted long-term survival of patients with renal failure, β2 microglobulin-derived amyloidosis is a serious complication occurring most commonly in long-term hemodialysis patients. Orthopedic manifestations are quite common, but cutaneous and lingual manifestations are relatively uncommon. We report a 56-year-old patient with lichenoid plaque type of skin eruptions and lingual papules caused by β2 microglobulin-derived amyloidosis. Immunohistochemical study showed that amyloid deposits were positive for anti-β2 microglobulin antibody, but negative for anti-advanced glycation end products antibody (anti-CML and CLE antibody). We discuss the histological and the clinical features of skin manifestations of β2 microglobulin-derived amyloidosis.

Original languageEnglish
Pages (from-to)393-395
Number of pages3
JournalEuropean Journal of Dermatology
Volume13
Issue number4
Publication statusPublished - Jul 2003

All Science Journal Classification (ASJC) codes

  • Dermatology

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