Cutting edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B

Hathairat Thananchai, Geraldine Gillespie, Maureen P. Martin, Arman Bashirova, Nobuyo Yawata, Makoto Yawata, Philippa Easterbrook, Daniel W. McVicar, Katsumi Maenaka, Peter Parham, Mary Carrington, Tao Dong, Sarah Rowland-Jones

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

Although it is clear that KIR3DL1 recognizes Bw4+ HLA-B, the role of Bw4+ HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4+ HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotypes. Only Bw4+ tetramers bound KIR3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and all four KIR3DL1 allotypes bound to one or more HLA-A*2402 tetramers, but with different binding specificities. Only KIR3DL1*005 bound both HLA-A*2402 and HLA-B*5703 tetramers. HLA-A*2402-expressing target cells were resistant to lysis by NK cells expressing KIR3DL1*001 or *005. This study shows that HLAA*2402 is a ligand for KIR3DL1 and demonstrates how the binding of KIR3DL1 to Bw4+ ligands depends upon the bound peptide as well as HLA and KIR3DL1 polymorphism.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalJournal of Immunology
Volume178
Issue number1
DOIs
Publication statusPublished - Jan 1 2007
Externally publishedYes

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HLA-A Antigens
HLA-B Antigens
Alleles
Peptides
Ligands
Natural Killer Cells

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Thananchai, H., Gillespie, G., Martin, M. P., Bashirova, A., Yawata, N., Yawata, M., ... Rowland-Jones, S. (2007). Cutting edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. Journal of Immunology, 178(1), 33-37. https://doi.org/10.4049/jimmunol.178.1.33

Cutting edge : Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. / Thananchai, Hathairat; Gillespie, Geraldine; Martin, Maureen P.; Bashirova, Arman; Yawata, Nobuyo; Yawata, Makoto; Easterbrook, Philippa; McVicar, Daniel W.; Maenaka, Katsumi; Parham, Peter; Carrington, Mary; Dong, Tao; Rowland-Jones, Sarah.

In: Journal of Immunology, Vol. 178, No. 1, 01.01.2007, p. 33-37.

Research output: Contribution to journalArticle

Thananchai, H, Gillespie, G, Martin, MP, Bashirova, A, Yawata, N, Yawata, M, Easterbrook, P, McVicar, DW, Maenaka, K, Parham, P, Carrington, M, Dong, T & Rowland-Jones, S 2007, 'Cutting edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B', Journal of Immunology, vol. 178, no. 1, pp. 33-37. https://doi.org/10.4049/jimmunol.178.1.33
Thananchai, Hathairat ; Gillespie, Geraldine ; Martin, Maureen P. ; Bashirova, Arman ; Yawata, Nobuyo ; Yawata, Makoto ; Easterbrook, Philippa ; McVicar, Daniel W. ; Maenaka, Katsumi ; Parham, Peter ; Carrington, Mary ; Dong, Tao ; Rowland-Jones, Sarah. / Cutting edge : Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. In: Journal of Immunology. 2007 ; Vol. 178, No. 1. pp. 33-37.
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