Cutting edge: Critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance

Xiaofeng Jiang, Takeshi Shimaoka, Satoshi Kojo, Michishige Harada, Hiroshi Watarai, Hiroshi Wakao, Nobuhiro Ohkohchi, Shin Yonehara, Masaru Taniguchi, Ken Ichiro Seino

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

It is well-documented that certain chemokines or their receptors play important roles in the graft rejection. However, the roles of chemokines and their receptors in the maintenance of transplantation tolerance remain unclear. In this study, we demonstrate that blocking of the interaction between the chemokine receptor, CXCR6, highly expressed on Vα14+ NKT cells and its ligand, CXCL16, resulted in the failure to maintain graft tolerance and thus in the induction of acceleration of graft rejection. In a mouse transplant tolerance model, the expression of CXCL16 was up-regulated in the tolerated allografts, and anti-CXCL16 mAb inhibited intragraft accumulation of NKT cells. In vitro experiments farther showed that blocking of CXCL16/CXCR6 interaction significantly affected not only chemotaxis but also cell adhesion of NKT cells. These results demonstrate the unique role of CXCL16 and CXCR6 molecules in the maintenance of cardiac allograft tolerance mediated by NKT cells.

Original languageEnglish
Pages (from-to)2051-2055
Number of pages5
JournalJournal of Immunology
Volume175
Issue number4
DOIs
Publication statusPublished - Aug 15 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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