Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase

Haruhiro Higashida; Minako Hashii; Shigeru Yokoyama; Naoto Hoshi; Xiao Lian Chen; Alla Egorova; Mami Noda; Jia Sheng Zhang

doi:10.1016/S0163-7258(01)00142-5

Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase

Haruhiro Higashida, Minako Hashii, Shigeru Yokoyama, Naoto Hoshi, Xiao Lian Chen, Alla Egorova, Mami Noda, Jia Sheng Zhang

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Review article › peer-review

55 Citations (Scopus)

Abstract

Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca²⁺-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca²⁺ concentrations or potentiates Ca²⁺ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca²⁺ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.

Original language	English
Pages (from-to)	283-296
Number of pages	14
Journal	Pharmacology and Therapeutics
Volume	90
Issue number	2-3
DOIs	https://doi.org/10.1016/S0163-7258(01)00142-5
Publication status	Published - 2001

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)

Access to Document

10.1016/S0163-7258(01)00142-5

Cite this

Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase. / Higashida, Haruhiro; Hashii, Minako; Yokoyama, Shigeru; Hoshi, Naoto; Chen, Xiao Lian; Egorova, Alla; Noda, Mami; Zhang, Jia Sheng.

In: Pharmacology and Therapeutics, Vol. 90, No. 2-3, 2001, p. 283-296.

Research output: Contribution to journal › Review article › peer-review

@article{41cf2c1e608a4ea2a42a82de37d4f11c,

title = "Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase",

abstract = "Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.",

author = "Haruhiro Higashida and Minako Hashii and Shigeru Yokoyama and Naoto Hoshi and Chen, {Xiao Lian} and Alla Egorova and Mami Noda and Zhang, {Jia Sheng}",

year = "2001",

doi = "10.1016/S0163-7258(01)00142-5",

language = "English",

volume = "90",

pages = "283--296",

journal = "Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and",

issn = "0163-7258",

publisher = "Elsevier Inc.",

number = "2-3",

}

TY - JOUR

T1 - Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase

AU - Higashida, Haruhiro

AU - Hashii, Minako

AU - Yokoyama, Shigeru

AU - Hoshi, Naoto

AU - Chen, Xiao Lian

AU - Egorova, Alla

AU - Noda, Mami

AU - Zhang, Jia Sheng

PY - 2001

Y1 - 2001

N2 - Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.

AB - Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.

UR - http://www.scopus.com/inward/record.url?scp=0034802462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034802462&partnerID=8YFLogxK

U2 - 10.1016/S0163-7258(01)00142-5

DO - 10.1016/S0163-7258(01)00142-5

M3 - Review article

C2 - 11578661

AN - SCOPUS:0034802462

VL - 90

SP - 283

EP - 296

JO - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and

JF - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and

SN - 0163-7258

IS - 2-3

ER -

Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this