TY - JOUR
T1 - Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase
AU - Higashida, Haruhiro
AU - Hashii, Minako
AU - Yokoyama, Shigeru
AU - Hoshi, Naoto
AU - Chen, Xiao Lian
AU - Egorova, Alla
AU - Noda, Mami
AU - Zhang, Jia Sheng
PY - 2001
Y1 - 2001
N2 - Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.
AB - Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.
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U2 - 10.1016/S0163-7258(01)00142-5
DO - 10.1016/S0163-7258(01)00142-5
M3 - Review article
C2 - 11578661
AN - SCOPUS:0034802462
VL - 90
SP - 283
EP - 296
JO - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
JF - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
SN - 0163-7258
IS - 2-3
ER -