Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase

Haruhiro Higashida, Minako Hashii, Shigeru Yokoyama, Naoto Hoshi, Xiao Lian Chen, Alla Egorova, Mami Noda, Jia Sheng Zhang

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)

Abstract

Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+-releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed.

Original languageEnglish
Pages (from-to)283-296
Number of pages14
JournalPharmacology and Therapeutics
Volume90
Issue number2-3
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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