TY - JOUR
T1 - Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system
AU - Higashida, Haruhiro
AU - Salmina, Alla B.
AU - Olovyannikova, Raissa Ya
AU - Hashii, Minako
AU - Yokoyama, Shigeru
AU - Koizumi, Keita
AU - Jin, Duo
AU - Liu, Hong Xiang
AU - Lopatina, Olga
AU - Amina, Sarwat
AU - Islam, Mohammad Saharul
AU - Huang, Jian Jun
AU - Noda, Mami
PY - 2007/7
Y1 - 2007/7
N2 - β-NAD+ is as abundant as ATP in neuronal cells. β-NAD+ functions not only as a coenzyme but also as a substrate. β-NAD+-utilizing enzymes are involved in signal transduction. We focus on ADP-ribosyl cyclase/CD38 which synthesizes cyclic ADP-ribose (cADPR), a universal Ca2+ mobilizer from intracellular stores, from β-NAD+. cADPR acts through activation/modulation of ryanodine receptor Ca2+ releasing Ca2+ channels. cADPR synthesis in neuronal cells is stimulated or modulated via different pathways and various factors. Subtype-specific coupling of various neurotransmitter receptors with ADP-ribosyl cyclase confirms the involvement of the enzyme in signal transduction in neurons and glial cells. Moreover, cADPR/CD38 is critical in oxytocin release from the hypothalamic cell dendrites and nerve terminals in the posterior pituitary. Therefore, it is possible that pharmacological manipulation of intracellular cADPR levels through ADP-ribosyl cyclase activity or synthetic cADPR analogues may provide new therapeutic opportunities for treatment of neurodevelopmental disorders.
AB - β-NAD+ is as abundant as ATP in neuronal cells. β-NAD+ functions not only as a coenzyme but also as a substrate. β-NAD+-utilizing enzymes are involved in signal transduction. We focus on ADP-ribosyl cyclase/CD38 which synthesizes cyclic ADP-ribose (cADPR), a universal Ca2+ mobilizer from intracellular stores, from β-NAD+. cADPR acts through activation/modulation of ryanodine receptor Ca2+ releasing Ca2+ channels. cADPR synthesis in neuronal cells is stimulated or modulated via different pathways and various factors. Subtype-specific coupling of various neurotransmitter receptors with ADP-ribosyl cyclase confirms the involvement of the enzyme in signal transduction in neurons and glial cells. Moreover, cADPR/CD38 is critical in oxytocin release from the hypothalamic cell dendrites and nerve terminals in the posterior pituitary. Therefore, it is possible that pharmacological manipulation of intracellular cADPR levels through ADP-ribosyl cyclase activity or synthetic cADPR analogues may provide new therapeutic opportunities for treatment of neurodevelopmental disorders.
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U2 - 10.1016/j.neuint.2007.06.023
DO - 10.1016/j.neuint.2007.06.023
M3 - Review article
C2 - 17664018
AN - SCOPUS:34547459564
SN - 0197-0186
VL - 51
SP - 192
EP - 199
JO - Neurochemistry International
JF - Neurochemistry International
IS - 2-4 SPEC. ISS.
ER -