Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system

Haruhiro Higashida, Alla B. Salmina, Raissa Ya Olovyannikova, Minako Hashii, Shigeru Yokoyama, Keita Koizumi, Duo Jin, Hong Xiang Liu, Olga Lopatina, Sarwat Amina, Mohammad Saharul Islam, Jian Jun Huang, Mami Noda

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

β-NAD+ is as abundant as ATP in neuronal cells. β-NAD+ functions not only as a coenzyme but also as a substrate. β-NAD+-utilizing enzymes are involved in signal transduction. We focus on ADP-ribosyl cyclase/CD38 which synthesizes cyclic ADP-ribose (cADPR), a universal Ca2+ mobilizer from intracellular stores, from β-NAD+. cADPR acts through activation/modulation of ryanodine receptor Ca2+ releasing Ca2+ channels. cADPR synthesis in neuronal cells is stimulated or modulated via different pathways and various factors. Subtype-specific coupling of various neurotransmitter receptors with ADP-ribosyl cyclase confirms the involvement of the enzyme in signal transduction in neurons and glial cells. Moreover, cADPR/CD38 is critical in oxytocin release from the hypothalamic cell dendrites and nerve terminals in the posterior pituitary. Therefore, it is possible that pharmacological manipulation of intracellular cADPR levels through ADP-ribosyl cyclase activity or synthetic cADPR analogues may provide new therapeutic opportunities for treatment of neurodevelopmental disorders.

Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalNeurochemistry International
Volume51
Issue number2-4 SPEC. ISS.
DOIs
Publication statusPublished - Jul 1 2007

Fingerprint

Cyclic ADP-Ribose
Nervous System
ADP-ribosyl Cyclase
Calcium
NAD
Signal Transduction
Neurons
Ryanodine Receptor Calcium Release Channel
Neurotransmitter Receptor
Coenzymes
Oxytocin
Enzymes
Dendrites
Neuroglia
Adenosine Triphosphate
Pharmacology

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Higashida, H., Salmina, A. B., Olovyannikova, R. Y., Hashii, M., Yokoyama, S., Koizumi, K., ... Noda, M. (2007). Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. Neurochemistry International, 51(2-4 SPEC. ISS.), 192-199. https://doi.org/10.1016/j.neuint.2007.06.023

Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. / Higashida, Haruhiro; Salmina, Alla B.; Olovyannikova, Raissa Ya; Hashii, Minako; Yokoyama, Shigeru; Koizumi, Keita; Jin, Duo; Liu, Hong Xiang; Lopatina, Olga; Amina, Sarwat; Islam, Mohammad Saharul; Huang, Jian Jun; Noda, Mami.

In: Neurochemistry International, Vol. 51, No. 2-4 SPEC. ISS., 01.07.2007, p. 192-199.

Research output: Contribution to journalReview article

Higashida, H, Salmina, AB, Olovyannikova, RY, Hashii, M, Yokoyama, S, Koizumi, K, Jin, D, Liu, HX, Lopatina, O, Amina, S, Islam, MS, Huang, JJ & Noda, M 2007, 'Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system', Neurochemistry International, vol. 51, no. 2-4 SPEC. ISS., pp. 192-199. https://doi.org/10.1016/j.neuint.2007.06.023
Higashida H, Salmina AB, Olovyannikova RY, Hashii M, Yokoyama S, Koizumi K et al. Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. Neurochemistry International. 2007 Jul 1;51(2-4 SPEC. ISS.):192-199. https://doi.org/10.1016/j.neuint.2007.06.023
Higashida, Haruhiro ; Salmina, Alla B. ; Olovyannikova, Raissa Ya ; Hashii, Minako ; Yokoyama, Shigeru ; Koizumi, Keita ; Jin, Duo ; Liu, Hong Xiang ; Lopatina, Olga ; Amina, Sarwat ; Islam, Mohammad Saharul ; Huang, Jian Jun ; Noda, Mami. / Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. In: Neurochemistry International. 2007 ; Vol. 51, No. 2-4 SPEC. ISS. pp. 192-199.
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