Cyclin D1 Overexpression in Laryngeal Carcinomas

Xue Feng Wang, Torahiko Nakashima, Muneyuki Masuda, Katsuko Matsui, Tomoya Yamamoto, Sohtaro Komiyama

Research output: Contribution to journalArticle

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Abstract

Overexpression of cyclin D1 has been found in a variety of malignancies and is suggested to be related to tumor progression. We immunohistochemically investigated the overexpression of cyclin D1 protein in 92 laryngeal carcinomas. Twenty-eight (30.4%) of the carcinoma specimens showed overexpression of cyclin D1. This overexpression was not related to the tumor stage, lymph node matastasis, or clinical outcome. However, the overexpression of cyclin D1 in patients with local recurrence was significantly higher than in patients with no recurrence. Cyclin D1 immunohistochemical staining is considered to be a useful marker for predicting tumor recurrence.

Original languageEnglish
Pages (from-to)212-215
Number of pages4
JournalJournal of Otolaryngology of Japan
Volume101
Issue number2
DOIs
Publication statusPublished - Jan 1 1998

Fingerprint

Cyclin D1
Carcinoma
Recurrence
Neoplasms
Tumor Biomarkers
Lymph Nodes
Staining and Labeling
Proteins

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Wang, X. F., Nakashima, T., Masuda, M., Matsui, K., Yamamoto, T., & Komiyama, S. (1998). Cyclin D1 Overexpression in Laryngeal Carcinomas. Journal of Otolaryngology of Japan, 101(2), 212-215. https://doi.org/10.3950/jibiinkoka.101.212

Cyclin D1 Overexpression in Laryngeal Carcinomas. / Wang, Xue Feng; Nakashima, Torahiko; Masuda, Muneyuki; Matsui, Katsuko; Yamamoto, Tomoya; Komiyama, Sohtaro.

In: Journal of Otolaryngology of Japan, Vol. 101, No. 2, 01.01.1998, p. 212-215.

Research output: Contribution to journalArticle

Wang, XF, Nakashima, T, Masuda, M, Matsui, K, Yamamoto, T & Komiyama, S 1998, 'Cyclin D1 Overexpression in Laryngeal Carcinomas', Journal of Otolaryngology of Japan, vol. 101, no. 2, pp. 212-215. https://doi.org/10.3950/jibiinkoka.101.212
Wang XF, Nakashima T, Masuda M, Matsui K, Yamamoto T, Komiyama S. Cyclin D1 Overexpression in Laryngeal Carcinomas. Journal of Otolaryngology of Japan. 1998 Jan 1;101(2):212-215. https://doi.org/10.3950/jibiinkoka.101.212
Wang, Xue Feng ; Nakashima, Torahiko ; Masuda, Muneyuki ; Matsui, Katsuko ; Yamamoto, Tomoya ; Komiyama, Sohtaro. / Cyclin D1 Overexpression in Laryngeal Carcinomas. In: Journal of Otolaryngology of Japan. 1998 ; Vol. 101, No. 2. pp. 212-215.
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