Cyclin D1 overexpression in laryngeal carcinomas

X. F. Wang, T. Nakashima, M. Masuda, K. Matsui, T. Yamamoto, S. Komiyama

Research output: Contribution to journalArticle

Abstract

Overexpression of cyclin D1 has been found in a variety of malignancies and is suggested to be related to tumor progression. We immunohistochemically investigated the overexpression of cyclin D1 protein in 92 laryngeal carcinomas. Twenty-eight (30.4%) of the carcinoma specimens showed overexpression of cyclin D1. This overexpression was not related to the tumor stage, lymph node metastasis, or clinical outcome. However, the overexpression of cyclin D1 in patients with local recurrence was significantly higher than in patients with no recurrence. Cyclin D1 immunohistochemical staining is considered to be a useful marker for predicting tumor recurrence.

Original languageEnglish
Pages (from-to)212-215
Number of pages4
JournalJournal of Otolaryngology of Japan
Volume101
Issue number2
Publication statusPublished - Feb 1998

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Cyclin D1
Carcinoma
Recurrence
Neoplasms
Tumor Biomarkers
Lymph Nodes
Staining and Labeling
Neoplasm Metastasis
Proteins

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Wang, X. F., Nakashima, T., Masuda, M., Matsui, K., Yamamoto, T., & Komiyama, S. (1998). Cyclin D1 overexpression in laryngeal carcinomas. Journal of Otolaryngology of Japan, 101(2), 212-215.

Cyclin D1 overexpression in laryngeal carcinomas. / Wang, X. F.; Nakashima, T.; Masuda, M.; Matsui, K.; Yamamoto, T.; Komiyama, S.

In: Journal of Otolaryngology of Japan, Vol. 101, No. 2, 02.1998, p. 212-215.

Research output: Contribution to journalArticle

Wang, XF, Nakashima, T, Masuda, M, Matsui, K, Yamamoto, T & Komiyama, S 1998, 'Cyclin D1 overexpression in laryngeal carcinomas', Journal of Otolaryngology of Japan, vol. 101, no. 2, pp. 212-215.
Wang XF, Nakashima T, Masuda M, Matsui K, Yamamoto T, Komiyama S. Cyclin D1 overexpression in laryngeal carcinomas. Journal of Otolaryngology of Japan. 1998 Feb;101(2):212-215.
Wang, X. F. ; Nakashima, T. ; Masuda, M. ; Matsui, K. ; Yamamoto, T. ; Komiyama, S. / Cyclin D1 overexpression in laryngeal carcinomas. In: Journal of Otolaryngology of Japan. 1998 ; Vol. 101, No. 2. pp. 212-215.
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