CYLD in Ubiquitin Signaling and Tumor Pathogenesis

Fumiyo Ikeda, Ivan Dikic

Research output: Contribution to journalShort survey

23 Citations (Scopus)

Abstract

Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors. In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-κB and activates transcription of proliferation genes in response to growth signals.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalCell
Volume125
Issue number4
DOIs
Publication statusPublished - May 19 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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