Abstract
Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors. In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-κB and activates transcription of proliferation genes in response to growth signals.
Original language | English |
---|---|
Pages (from-to) | 643-645 |
Number of pages | 3 |
Journal | Cell |
Volume | 125 |
Issue number | 4 |
DOIs | |
Publication status | Published - May 19 2006 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)