CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians

Kazuaki Sakai, Ernesto Loza, Guido Villa Gomez Roig, Ryoko Nozaki, Takao Asai, Toshikazu Ikoma, Yasuo Tsuchiya, Chikako Kiyohara, Masaharu Yamamoto, Kazutoshi Nakamura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Gallbladder Neoplasms
Cytochrome P-450 CYP1A1
Glutathione Transferase
Bolivia
Healthy Volunteers
Odds Ratio
Confidence Intervals
Genotype
Tumor Suppressor Protein p53
Multiplex Polymerase Chain Reaction
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Cytochrome P-450 Enzyme System
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Sakai, K., Loza, E., Roig, G. V. G., Nozaki, R., Asai, T., Ikoma, T., ... Nakamura, K. (2016). CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians. Asian Pacific Journal of Cancer Prevention, 17(2), 781-784. https://doi.org/10.7314/APJCP.2016.17.2.781

CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians. / Sakai, Kazuaki; Loza, Ernesto; Roig, Guido Villa Gomez; Nozaki, Ryoko; Asai, Takao; Ikoma, Toshikazu; Tsuchiya, Yasuo; Kiyohara, Chikako; Yamamoto, Masaharu; Nakamura, Kazutoshi.

In: Asian Pacific Journal of Cancer Prevention, Vol. 17, No. 2, 01.01.2016, p. 781-784.

Research output: Contribution to journalArticle

Sakai, K, Loza, E, Roig, GVG, Nozaki, R, Asai, T, Ikoma, T, Tsuchiya, Y, Kiyohara, C, Yamamoto, M & Nakamura, K 2016, 'CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians', Asian Pacific Journal of Cancer Prevention, vol. 17, no. 2, pp. 781-784. https://doi.org/10.7314/APJCP.2016.17.2.781
Sakai, Kazuaki ; Loza, Ernesto ; Roig, Guido Villa Gomez ; Nozaki, Ryoko ; Asai, Takao ; Ikoma, Toshikazu ; Tsuchiya, Yasuo ; Kiyohara, Chikako ; Yamamoto, Masaharu ; Nakamura, Kazutoshi. / CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians. In: Asian Pacific Journal of Cancer Prevention. 2016 ; Vol. 17, No. 2. pp. 781-784.
@article{988d3b3de3a34bcfae93851a97fd03f3,
title = "CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians",
abstract = "The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95{\%} confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95{\%} CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95{\%} CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.",
author = "Kazuaki Sakai and Ernesto Loza and Roig, {Guido Villa Gomez} and Ryoko Nozaki and Takao Asai and Toshikazu Ikoma and Yasuo Tsuchiya and Chikako Kiyohara and Masaharu Yamamoto and Kazutoshi Nakamura",
year = "2016",
month = "1",
day = "1",
doi = "10.7314/APJCP.2016.17.2.781",
language = "English",
volume = "17",
pages = "781--784",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "2",

}

TY - JOUR

T1 - CYP1A1, GSTM1, GSTT1 and TP53 polymorphisms and risk of gallbladder cancer in Bolivians

AU - Sakai, Kazuaki

AU - Loza, Ernesto

AU - Roig, Guido Villa Gomez

AU - Nozaki, Ryoko

AU - Asai, Takao

AU - Ikoma, Toshikazu

AU - Tsuchiya, Yasuo

AU - Kiyohara, Chikako

AU - Yamamoto, Masaharu

AU - Nakamura, Kazutoshi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.

AB - The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.

UR - http://www.scopus.com/inward/record.url?scp=84960431363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960431363&partnerID=8YFLogxK

U2 - 10.7314/APJCP.2016.17.2.781

DO - 10.7314/APJCP.2016.17.2.781

M3 - Article

C2 - 26925680

AN - SCOPUS:84960431363

VL - 17

SP - 781

EP - 784

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 2

ER -