CYP2E1 rs2031920, COMT rs4680 polymorphisms, cigarette smoking, alcohol use and lung cancer risk in a Japanese population

Kenichi Kakino, Chikako Kiyohara, Takahiko Horiuchi, Yoichi Nakanishi

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Abstract

Background: Cytochrome P450 2E1 (CYP2E1) and catechol-O-methyltransferase (COMT) genes may contribute to susceptiblity to lung cancer becuase of their critical involvement in mechanisms of carcinogenesis. Materials and Methods: We evaluated the role of CYP2E1 rs2031920 and COMT rs4680 in a case-control study involving 462 lung cancer cases and 379 controls in Japanese. Logistic regression was used to assess adjusted odds ratios (OR) and 95% confidence intervals (CI). Multiplicative and additive interactions with cigarette smoking or alcohol use were also examined. Results: Neither CYP2E1 rs2031920 nor COMT rs4680 was associated with lung cancer risk overall. However, smokers with the CC genotype of CYP2E1 rs2031920 (OR = 3.57, 95% CI = 2.26-5.63) presented a higher risk of lung cancer than those with at least one T allele (OR = 2.91, 95% CI = 1.70-4.98) as compared to never-smokers with at least one T allele (reference). Subjects with excessive drinking and the CC genotype of CYP2E1 rs2031920 had a significantly higher risk (OR = 2.22, 95% CI =1.39-3.56) than appropriate drinkers with at least one T allele. A similar tendency was observed between COMT rs4680 and either smoking or drinking habits. There were no multiplicative or additive interactions between the polymorphisms and either smoking or alcohol use. Conclusions: Our findings indicate that CYP2E1 rs2031920 and COMT rs4680 are not major contributors to lung cancer risk in our Japanese population. Future studies on the genetics of lung cancer in Japanese and their environment interactions are required.

Original languageEnglish
Pages (from-to)4065-4072
Number of pages8
JournalAsian Pacific Journal of Cancer Prevention
Volume17
Issue number8
Publication statusPublished - Jan 1 2016

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Catechol O-Methyltransferase
Cytochrome P-450 CYP2E1
Lung Neoplasms
Smoking
Alcohols
Odds Ratio
Confidence Intervals
Population
Alleles
Drinking
Genotype
Habits
Case-Control Studies
Carcinogenesis
Logistic Models
Genes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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CYP2E1 rs2031920, COMT rs4680 polymorphisms, cigarette smoking, alcohol use and lung cancer risk in a Japanese population. / Kakino, Kenichi; Kiyohara, Chikako; Horiuchi, Takahiko; Nakanishi, Yoichi.

In: Asian Pacific Journal of Cancer Prevention, Vol. 17, No. 8, 01.01.2016, p. 4065-4072.

Research output: Contribution to journalArticle

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