Cytochrome P450-dependent change in UDP-glucuronosyltransferase function and its reverse regulation

Yuji Ishii, Yuu Miyauchi, Hideyuki Yamada

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cytochrome P450 (P450, CYP) and UDP-glucuronosyltransferase (UGT) are important enzymes involved in phase I and II drug metabolism, respectively. It has long been believed that these enzymes work separately, because their topology with regard to the endoplasmic reticulum membrane is very different and the location of the two enzymes is separated by the membrane. However, cumulative evidence suggests that these enzymes interact with each other to modify their respective functions. This review mainly focuses on a P450-dependent alteration in UGT function and discusses the relevance of this modification to the polymorphic nature of drug metabolism mediated by UGTs. Also, we describe the selectivity of P450/UGT isoforms in terms of their pairing and possible P450/UGT domains serving the interactions. The reverse modulation, that is, the alteration of P450 function by UGT, is also described.

Original languageEnglish
Title of host publicationFifty Years of Cytochrome P450 Research
PublisherSpringer Japan
Pages307-326
Number of pages20
ISBN (Electronic)9784431549925
ISBN (Print)9784431549918
DOIs
Publication statusPublished - Jan 1 2014

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ishii, Y., Miyauchi, Y., & Yamada, H. (2014). Cytochrome P450-dependent change in UDP-glucuronosyltransferase function and its reverse regulation. In Fifty Years of Cytochrome P450 Research (pp. 307-326). Springer Japan. https://doi.org/10.1007/978-4-431-54992-5_18