Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalJournal of the Ceramic Society of Japan
Volume114
Issue number1325
DOIs
Publication statusPublished - Jan 1 2006

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

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