Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki; Kanji Tsuru; Satoshi Hayakawa; Akiyoshi Osaka; Seisuke Takashima

doi:10.2109/jcersj.114.72

Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

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5 Citations (Scopus)

Abstract

γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

Original language	English
Pages (from-to)	72-76
Number of pages	5
Journal	Journal of the Ceramic Society of Japan
Volume	114
Issue number	1325
DOIs	https://doi.org/10.2109/jcersj.114.72
Publication status	Published - Jan 1 2006

All Science Journal Classification (ASJC) codes

Ceramics and Composites
Chemistry(all)
Condensed Matter Physics
Materials Chemistry

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title = "Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane",

abstract = "γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.",

author = "Yuki Shirosaki and Kanji Tsuru and Satoshi Hayakawa and Akiyoshi Osaka and Seisuke Takashima",

year = "2006",

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T1 - Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

AU - Shirosaki, Yuki

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

AU - Takashima, Seisuke

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AB - γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

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