Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

Peng Chen, Maki Ashida, Hisashi Doi, Yusuke Tsutsumi, Zenji Horita, Takao Hanawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.

Original languageEnglish
Pages (from-to)2020-2025
Number of pages6
JournalMaterials Transactions
Volume57
Issue number12
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Titanium
Torsional stress
torsion
titanium
Processing
cultured cells
trends
phosphatases
locomotion
Cell adhesion
Phosphatases
titanium alloys
immobilization
Titanium alloys
Alkaline Phosphatase
mice
adhesion
grain size

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Chen, P., Ashida, M., Doi, H., Tsutsumi, Y., Horita, Z., & Hanawa, T. (2016). Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing. Materials Transactions, 57(12), 2020-2025. https://doi.org/10.2320/matertrans.MI201515

Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing. / Chen, Peng; Ashida, Maki; Doi, Hisashi; Tsutsumi, Yusuke; Horita, Zenji; Hanawa, Takao.

In: Materials Transactions, Vol. 57, No. 12, 01.01.2016, p. 2020-2025.

Research output: Contribution to journalArticle

Chen, P, Ashida, M, Doi, H, Tsutsumi, Y, Horita, Z & Hanawa, T 2016, 'Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing', Materials Transactions, vol. 57, no. 12, pp. 2020-2025. https://doi.org/10.2320/matertrans.MI201515
Chen, Peng ; Ashida, Maki ; Doi, Hisashi ; Tsutsumi, Yusuke ; Horita, Zenji ; Hanawa, Takao. / Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing. In: Materials Transactions. 2016 ; Vol. 57, No. 12. pp. 2020-2025.
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