Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells

Tomoki Naoe, Yukihiro Akao, Kazumasa Yamada, Kazuhiko R. Utsumi, Koichi Koike, Michihiro Shamoto, Katsuo Koie, Yoshikazu Kurosawa, Koji Kato, Masumi Abe, Hiroshi Shiku

Research output: Contribution to journalArticle

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Abstract

A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalCancer Genetics and Cytogenetics
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 1988
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
Cytogenetics
Chromosome Aberrations
T-Cell Receptor Genes
T-Lymphocytes
Cell Line
Immunoglobulin Heavy Chains
Human T-lymphotropic virus 1
Blood Cells
Genome
Phenotype

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells. / Naoe, Tomoki; Akao, Yukihiro; Yamada, Kazumasa; Utsumi, Kazuhiko R.; Koike, Koichi; Shamoto, Michihiro; Koie, Katsuo; Kurosawa, Yoshikazu; Kato, Koji; Abe, Masumi; Shiku, Hiroshi.

In: Cancer Genetics and Cytogenetics, Vol. 34, No. 1, 01.01.1988, p. 77-88.

Research output: Contribution to journalArticle

Naoe, T, Akao, Y, Yamada, K, Utsumi, KR, Koike, K, Shamoto, M, Koie, K, Kurosawa, Y, Kato, K, Abe, M & Shiku, H 1988, 'Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells', Cancer Genetics and Cytogenetics, vol. 34, no. 1, pp. 77-88. https://doi.org/10.1016/0165-4608(88)90171-9
Naoe, Tomoki ; Akao, Yukihiro ; Yamada, Kazumasa ; Utsumi, Kazuhiko R. ; Koike, Koichi ; Shamoto, Michihiro ; Koie, Katsuo ; Kurosawa, Yoshikazu ; Kato, Koji ; Abe, Masumi ; Shiku, Hiroshi. / Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells. In: Cancer Genetics and Cytogenetics. 1988 ; Vol. 34, No. 1. pp. 77-88.
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