Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells

Tomoki Naoe, Yukihiro Akao, Kazumasa Yamada, Kazuhiko R. Utsumi, Koichi Koike, Michihiro Shamoto, Katsuo Koie, Yoshikazu Kurosawa, Koji Kato, Masumi Abe, Hiroshi Shiku

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalCancer Genetics and Cytogenetics
Volume34
Issue number1
DOIs
Publication statusPublished - Aug 1988

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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