Abstract
A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.
| Original language | English |
|---|---|
| Pages (from-to) | 77-88 |
| Number of pages | 12 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 1988 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Genetics
- Cancer Research
Cite this
Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells. / Naoe, Tomoki; Akao, Yukihiro; Yamada, Kazumasa; Utsumi, Kazuhiko R.; Koike, Koichi; Shamoto, Michihiro; Koie, Katsuo; Kurosawa, Yoshikazu; Kato, Koji; Abe, Masumi; Shiku, Hiroshi.
In: Cancer Genetics and Cytogenetics, Vol. 34, No. 1, 01.01.1988, p. 77-88.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells
AU - Naoe, Tomoki
AU - Akao, Yukihiro
AU - Yamada, Kazumasa
AU - Utsumi, Kazuhiko R.
AU - Koike, Koichi
AU - Shamoto, Michihiro
AU - Koie, Katsuo
AU - Kurosawa, Yoshikazu
AU - Kato, Koji
AU - Abe, Masumi
AU - Shiku, Hiroshi
PY - 1988/1/1
Y1 - 1988/1/1
N2 - A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.
AB - A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.
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U2 - 10.1016/0165-4608(88)90171-9
DO - 10.1016/0165-4608(88)90171-9
M3 - Article
VL - 34
SP - 77
EP - 88
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -