TY - JOUR
T1 - Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells
AU - Naoe, Tomoki
AU - Akao, Yukihiro
AU - Yamada, Kazumasa
AU - Utsumi, Kazuhiko R.
AU - Koike, Koichi
AU - Shamoto, Michihiro
AU - Koie, Katsuo
AU - Kurosawa, Yoshikazu
AU - Kato, Koji
AU - Abe, Masumi
AU - Shiku, Hiroshi
PY - 1988/8
Y1 - 1988/8
N2 - A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.
AB - A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.
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U2 - 10.1016/0165-4608(88)90171-9
DO - 10.1016/0165-4608(88)90171-9
M3 - Article
C2 - 3260813
AN - SCOPUS:0023705965
VL - 34
SP - 77
EP - 88
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -
