Cytokeratin subunits of inclusion bodies in rhabdoid cells: Immunohistochemical and clinicopathological study of malignant rhabdoid tumor and epithelioid sarcoma

Hideki Shiratsuchi, Yumi Oshiro, Tsuyoshi Saito, Eijun Itakura, Yoshiaki Kinoshita, Sadafumi Tamiya, Yoshinao Oda, Sohtaro Komiyama, Masazumi Tsuneyoshi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Extrarenal malignant rhabdoid tumor (MRT), which is recognized as being histologically similar to renal MRT, is characterized by the presence of "rhabdoid cell" (RC) and a highly aggressive biological behavior. Recently it has been proposed that "proximal variant" of epithelioid sarcoma (ES), whose morphology is similar to that of MRT, actually has a more aggressive clinical course than classical type ES. Detailed immunohistochemical analysis of cytokeratin (CK) subunits was performed in 3 cases of extrarenal MRT, 3 cases of renal MRT, and 11 cases of ES comprising 2 "proximal variants" and 9 classical types. Renal and extrarenal MRTs showed positive immunoreactivity for both CK8 and CK18. Classical type ESs were diffusely positive, not only for CK8 and CK18, but also for other cytokeratin subunits including CK4, 6, 10, 13, 16, 17, and "high-molecular-weight" CKs (CK1, 5, 10, and 14). On the other hand, proximal ES revealed limited immunohistochemical reactivity for cytokeratins, compared with classical ES. In conclusion, the inclusion bodies of RCs show immunoreactivity confined to CK8, CK18, and vimentin. Furthermore, ES has additional CK expressions, while proximal ES possesses characteristics intermediate between those of classical ES and those of external MRT.

Original languageEnglish
Pages (from-to)37-48
Number of pages12
JournalInternational Journal of Surgical Pathology
Volume9
Issue number1
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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