Cytokines and chemokines in the epidermis

Uchi Hiroshi, Hiroshi Terao, Tetsuya Koga, Masutaka Furue

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Keratinocytes (KC) produce a vast repertoire of cytokines, including interleukins, growth factors, colony stimulating factors, and chemokines. Under normal conditions, most of them are not synthesized or remain in the cytoplasm, but external stimuli, such as trauma, bacterial infections, chemical substances, or ultraviolet irradiation induce the production and release of these cytokines from KC. KC-derived cytokines regulate the immune and inflammatory responses through their receptors on KC, Langerhans cells, dermal fibroblasts and endothelial cells, and infiltrating T-cells.

Original languageEnglish
JournalJournal of Dermatological Science
Volume24
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 1 2000

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Keratinocytes
Chemokines
Epidermis
Cytokines
Colony-Stimulating Factors
T-cells
Langerhans Cells
Interleukins
Endothelial cells
Fibroblasts
Bacterial Infections
Intercellular Signaling Peptides and Proteins
Cytoplasm
Endothelial Cells
Irradiation
T-Lymphocytes
Skin
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Cytokines and chemokines in the epidermis. / Hiroshi, Uchi; Terao, Hiroshi; Koga, Tetsuya; Furue, Masutaka.

In: Journal of Dermatological Science, Vol. 24, No. SUPPL. 1, 01.01.2000.

Research output: Contribution to journalArticle

Hiroshi, Uchi ; Terao, Hiroshi ; Koga, Tetsuya ; Furue, Masutaka. / Cytokines and chemokines in the epidermis. In: Journal of Dermatological Science. 2000 ; Vol. 24, No. SUPPL. 1.
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