Cytological study of early cervical adenocarcinoma: Special reference to the depth of invasion

Tsunehisa Kaku, Y. Kawano, T. Hirakawa, Y. Koga, H. Kobayashi, S. Amada, S. Ogawa, T. Hagiwara, S. Watanabe, H. Nakano

Research output: Contribution to journalArticle

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Abstract

Objective: Early cervical adenocarcinoma (ECA) with a tumour depth of <3 mm has a good prognosis. To clarify the cytological features of ECAs with depth <3 mm, these were compared with those of ECA with 3-5 mm and invasive adenocarcinoma (IA) invading the cervical wall with more than 5 mm in depth. Methods: The cervical cytological features of ECAs with depth <3 mm (14 cases) were compared with those of ECA with 3-5 mm (four cases) and IA (13 cases). Cytologically, the presence or absence of tumour diathesis, number of atypical cells, crowded cell groups, groups with glandular structures, feathering, groups with palisading borders, rosettes, clusters, cell shape and size, nuclear shape and size, nucleolar shape and size, chromatin distribution, border and character of cytoplasm, and single cell pattern were evaluated. Results: A tumour diathesis was seen in five of 14 ECA <3 mm in depth (36%), all four ECA with 3-5 mm (100%) and 11 of 13 IA with more than 5 mm (85%). Single cells, macronucleoli and coarsely granular chromatin pattern were less frequent in ECA of <3 mm than that in ECA with 3-5 mm and IA. The number of atypical cells and glandular structures in ECA was significantly less than that in IA. Cell crowding, feathering, palisading and rosettes were common in both ECA and IA. Conclusion: The characteristic cytological features of ECA with depth <3 mm, having a good prognosis, were clean background, fewer single cells and macronucleoli, and less frequent coarsely granular chromatin pattern compared with those in ECA with 3-5 mm and IA. The number of atypical cells and glandular structures in ECA was significantly less than that in IA. Familiarity with the cytological features of ECA and its mimics is essential.

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalCytopathology
Volume16
Issue number6
DOIs
Publication statusPublished - Dec 1 2005

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Adenocarcinoma
Chromatin
Cell Count
Disease Susceptibility
Group Structure
Neoplasms
Crowding
Cell Shape
Cell Size

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Kaku, T., Kawano, Y., Hirakawa, T., Koga, Y., Kobayashi, H., Amada, S., ... Nakano, H. (2005). Cytological study of early cervical adenocarcinoma: Special reference to the depth of invasion. Cytopathology, 16(6), 290-294. https://doi.org/10.1111/j.1365-2303.2005.00272.x

Cytological study of early cervical adenocarcinoma : Special reference to the depth of invasion. / Kaku, Tsunehisa; Kawano, Y.; Hirakawa, T.; Koga, Y.; Kobayashi, H.; Amada, S.; Ogawa, S.; Hagiwara, T.; Watanabe, S.; Nakano, H.

In: Cytopathology, Vol. 16, No. 6, 01.12.2005, p. 290-294.

Research output: Contribution to journalArticle

Kaku, T, Kawano, Y, Hirakawa, T, Koga, Y, Kobayashi, H, Amada, S, Ogawa, S, Hagiwara, T, Watanabe, S & Nakano, H 2005, 'Cytological study of early cervical adenocarcinoma: Special reference to the depth of invasion', Cytopathology, vol. 16, no. 6, pp. 290-294. https://doi.org/10.1111/j.1365-2303.2005.00272.x
Kaku, Tsunehisa ; Kawano, Y. ; Hirakawa, T. ; Koga, Y. ; Kobayashi, H. ; Amada, S. ; Ogawa, S. ; Hagiwara, T. ; Watanabe, S. ; Nakano, H. / Cytological study of early cervical adenocarcinoma : Special reference to the depth of invasion. In: Cytopathology. 2005 ; Vol. 16, No. 6. pp. 290-294.
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abstract = "Objective: Early cervical adenocarcinoma (ECA) with a tumour depth of <3 mm has a good prognosis. To clarify the cytological features of ECAs with depth <3 mm, these were compared with those of ECA with 3-5 mm and invasive adenocarcinoma (IA) invading the cervical wall with more than 5 mm in depth. Methods: The cervical cytological features of ECAs with depth <3 mm (14 cases) were compared with those of ECA with 3-5 mm (four cases) and IA (13 cases). Cytologically, the presence or absence of tumour diathesis, number of atypical cells, crowded cell groups, groups with glandular structures, feathering, groups with palisading borders, rosettes, clusters, cell shape and size, nuclear shape and size, nucleolar shape and size, chromatin distribution, border and character of cytoplasm, and single cell pattern were evaluated. Results: A tumour diathesis was seen in five of 14 ECA <3 mm in depth (36{\%}), all four ECA with 3-5 mm (100{\%}) and 11 of 13 IA with more than 5 mm (85{\%}). Single cells, macronucleoli and coarsely granular chromatin pattern were less frequent in ECA of <3 mm than that in ECA with 3-5 mm and IA. The number of atypical cells and glandular structures in ECA was significantly less than that in IA. Cell crowding, feathering, palisading and rosettes were common in both ECA and IA. Conclusion: The characteristic cytological features of ECA with depth <3 mm, having a good prognosis, were clean background, fewer single cells and macronucleoli, and less frequent coarsely granular chromatin pattern compared with those in ECA with 3-5 mm and IA. The number of atypical cells and glandular structures in ECA was significantly less than that in IA. Familiarity with the cytological features of ECA and its mimics is essential.",
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AU - Kobayashi, H.

AU - Amada, S.

AU - Ogawa, S.

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