Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

Yasunobu Tokunaga, Katsuto Takenaka, Ryoukichi Asayama, Tsunefumi Shibuya

Research output: Contribution to journalArticle

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Abstract

We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide. Fine crackles were audible in the lower lungs bilaterally. Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood. Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalInternal Medicine
Volume35
Issue number6
DOIs
Publication statusPublished - Jan 1 1996

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Interstitial Lung Diseases
Cytomegalovirus
Systemic Lupus Erythematosus
Ganciclovir
X Ray Computed Tomography
Respiratory Sounds
Methylprednisolone
Immunosuppressive Agents
HLA Antigens
Prednisolone
Cyclophosphamide
Peroxidase
Leukocytes
Thorax
Monoclonal Antibodies
Staining and Labeling
Lung
Therapeutics
Hypoxia

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus. / Tokunaga, Yasunobu; Takenaka, Katsuto; Asayama, Ryoukichi; Shibuya, Tsunefumi.

In: Internal Medicine, Vol. 35, No. 6, 01.01.1996, p. 517-520.

Research output: Contribution to journalArticle

Tokunaga, Yasunobu ; Takenaka, Katsuto ; Asayama, Ryoukichi ; Shibuya, Tsunefumi. / Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus. In: Internal Medicine. 1996 ; Vol. 35, No. 6. pp. 517-520.
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