Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

Yasunobu Tokunaga; Katsuto Takenaka; Ryoukichi Asayama; Tsunefumi Shibuya

doi:10.2169/internalmedicine.35.517

Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

Yasunobu Tokunaga, Katsuto Takenaka, Ryoukichi Asayama, Tsunefumi Shibuya

Hematology, Oncology & Cardiovascular medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide. Fine crackles were audible in the lower lungs bilaterally. Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood. Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.

Original language	English
Pages (from-to)	517-520
Number of pages	4
Journal	Internal Medicine
Volume	35
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.35.517
Publication status	Published - Jun 1996

All Science Journal Classification (ASJC) codes

Internal Medicine

Access to Document

10.2169/internalmedicine.35.517

Cite this

@article{974847b9ff6646c5b7c9dcc981014a21,

title = "Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus",

abstract = "We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide. Fine crackles were audible in the lower lungs bilaterally. Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood. Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.",

author = "Yasunobu Tokunaga and Katsuto Takenaka and Ryoukichi Asayama and Tsunefumi Shibuya",

year = "1996",

month = jun,

doi = "10.2169/internalmedicine.35.517",

language = "English",

volume = "35",

pages = "517--520",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "6",

}

TY - JOUR

T1 - Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

AU - Tokunaga, Yasunobu

AU - Takenaka, Katsuto

AU - Asayama, Ryoukichi

AU - Shibuya, Tsunefumi

PY - 1996/6

Y1 - 1996/6

N2 - We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide. Fine crackles were audible in the lower lungs bilaterally. Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood. Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.

AB - We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide. Fine crackles were audible in the lower lungs bilaterally. Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood. Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=0029989770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029989770&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.35.517

DO - 10.2169/internalmedicine.35.517

M3 - Article

C2 - 8835609

AN - SCOPUS:0029989770

SN - 0918-2918

VL - 35

SP - 517

EP - 520

JO - Internal Medicine

JF - Internal Medicine

IS - 6

ER -

Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this