Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus

Yasunobu Tokunaga, Katsuto Takenaka, Ryoukichi Asayama, Tsunefumi Shibuya

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15 Citations (Scopus)


We report an unusual case of cytomegalovirus (CMV) interstitial pneumonitis (IP) occurring in a 51-year-old Japanese woman with systemic lupus erythematosus (SLE). She developed hypoxemia after intensive immunosuppressive therapy with prednisolone and cyclophosphamide. Fine crackles were audible in the lower lungs bilaterally. Chest X-ray and computed tomography confirmed the presence of IP. CMV-antigenemia was confirmed by immunological staining of leukocytes using the peroxidase-labeled monoclonal antibody, HRP-C7. Hypoxemia improved gradually on methylprednisolone pulse therapy and gancyclovir, and CMV-antigen positive leukocytes disappeared from the peripheral blood. Data suggest the importance of CMV as a cause of IP in SLE, and the usefulness of the assay for CMV-antigenemia with C7-HRP for rapid diagnosis.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalInternal Medicine
Issue number6
Publication statusPublished - Jun 1996

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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