Cytophotometric estimation of hepatocytes DNA in chronic liver diseases including schistosomiasis for detection of early preneoplastic changes.

M. M. Abdel Rahman, M. S. el-Hakim, M. K. Ahmed, S. A. Saleh, Sayed G el-D el Sayed G el-D, M. M. Arafa

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Abstract

No doubt chronic liver diseases due to schistosomiasis and other causes as virus hepatitis are not uncommon among Egyptian patients. Besides, neoplastic changes in such patients are always seen. So, the aim of this work was to evaluate the estimation of hepatocytes DNA in chronic liver diseases as a diagnostic feature for early preneoplastic changes in different groups of patients. These groups included (a) chronic persistent hepatitis, (b) chronic active hepatitis, (c) liver cirrhosis due to schistosomiasis and other causes & (d) hepatocellular carcinoma. The results were evaluated histochemically and histopathologically. It was concluded that the cytophotometic evidence of hepatocytes DNA in chronic liver diseases is a promising mean in detecting early preneoplastic changes.

Original languageEnglish
Pages (from-to)633-641
Number of pages9
JournalJournal of the Egyptian Society of Parasitology
Volume24
Issue number3
Publication statusPublished - Dec 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Abdel Rahman, M. M., el-Hakim, M. S., Ahmed, M. K., Saleh, S. A., el Sayed G el-D, S. G. E-D., & Arafa, M. M. (1994). Cytophotometric estimation of hepatocytes DNA in chronic liver diseases including schistosomiasis for detection of early preneoplastic changes. Journal of the Egyptian Society of Parasitology, 24(3), 633-641.