TY - JOUR
T1 - Cytophotometric study of nuclear DNA content in scirrhous gastric carcinoma
AU - Adachi, Yosuke
AU - Mori, Masaki
AU - Haraguchi, Masaru
AU - Sugimachi, Keizo
AU - Tsuneyoshi, Masazumi
PY - 1995/1
Y1 - 1995/1
N2 - We made a cytophotometric DNA analysis using 21 scirrhous gastric carcinomas (SGC), and compared the results with those of 12 undifferentiated type early gastric carcinomas (EGC) located in thegastric body. Nuclear DNA content of tumor cells was measured in the mucosa of SGC (SGCm), serosa of SGC (SGCs) and mucosa of EGC (EGCm). DNA distribution pattern was high ploid in 18 SGCm (86%), 16 SGCs (71%) and 4 EGCm (33%). Mean DNA content was 4.02c in SGCm, 3.91c in SGCs and 3.26c in EGCm. Percentage of tumor cells with a DNA content over 3c was 77.4% in SGCm, 69.1% in SGCs and 49.5% in EGCm. Statistically significant differences in these 3 factors were present between SGCm and EGCm, but absentbetween SGCm and SGCs. Furthermore, DNA distribution pattern was not different between the mucosa andserosa in 19 SGC (90%). The results suggest that most scirrhous gastric carcinomas are high ploid in origin and do not change their biologic behaviour throughout the tumor progression.
AB - We made a cytophotometric DNA analysis using 21 scirrhous gastric carcinomas (SGC), and compared the results with those of 12 undifferentiated type early gastric carcinomas (EGC) located in thegastric body. Nuclear DNA content of tumor cells was measured in the mucosa of SGC (SGCm), serosa of SGC (SGCs) and mucosa of EGC (EGCm). DNA distribution pattern was high ploid in 18 SGCm (86%), 16 SGCs (71%) and 4 EGCm (33%). Mean DNA content was 4.02c in SGCm, 3.91c in SGCs and 3.26c in EGCm. Percentage of tumor cells with a DNA content over 3c was 77.4% in SGCm, 69.1% in SGCs and 49.5% in EGCm. Statistically significant differences in these 3 factors were present between SGCm and EGCm, but absentbetween SGCm and SGCs. Furthermore, DNA distribution pattern was not different between the mucosa andserosa in 19 SGC (90%). The results suggest that most scirrhous gastric carcinomas are high ploid in origin and do not change their biologic behaviour throughout the tumor progression.
UR - http://www.scopus.com/inward/record.url?scp=0029061429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029061429&partnerID=8YFLogxK
U2 - 10.1080/00313029500169372
DO - 10.1080/00313029500169372
M3 - Article
C2 - 7603752
AN - SCOPUS:0029061429
SN - 0031-3025
VL - 27
SP - 5
EP - 7
JO - Pathology
JF - Pathology
IS - 1
ER -