Cytophotometrically determined DNA content, mitotic activity, and lymph node metastasis in clinical gastric cancer

D. Korenaga, A. Saito, H. Baba, A. Watanabe, T. Okamura, Yoshihiko Maehara, K. Sugimachi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Analyses of cytophotometrically determined DNA content and mitotic rate were carried out in 37 cases of gastric carcinoma to identify biologic significance of DNA abnormalities. Lymph node metastasis was also evaluated by DNA content and mitotic rate. According to the linear regression analysis, there were statistically significant correlations of mitotic rate with DNA variants such as the peak value, the mean value, and the frequency of cells with values exceeding tetraploid or hexaploid chromosome complement. There were significantly higher values for these DNA parameters in patients with lymph node metastasis compared with those without metastasis. Similarly, higher mitotic rates were observed in tumors with metastatic disease. Thus abnormal DNA fractions appear to be indicative of tumors with a high mitotic activity. The quantitative detection of the DNA abnormalities will provide pertinent biologic information required to predict the occurrence of metastasis in patients with gastric cancer.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalSurgery
Volume107
Issue number3
Publication statusPublished - Jan 1 1990

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Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
DNA
Tetraploidy
Linear Models
Neoplasms
Stomach
Chromosomes
Regression Analysis
Carcinoma

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Korenaga, D., Saito, A., Baba, H., Watanabe, A., Okamura, T., Maehara, Y., & Sugimachi, K. (1990). Cytophotometrically determined DNA content, mitotic activity, and lymph node metastasis in clinical gastric cancer. Surgery, 107(3), 262-267.

Cytophotometrically determined DNA content, mitotic activity, and lymph node metastasis in clinical gastric cancer. / Korenaga, D.; Saito, A.; Baba, H.; Watanabe, A.; Okamura, T.; Maehara, Yoshihiko; Sugimachi, K.

In: Surgery, Vol. 107, No. 3, 01.01.1990, p. 262-267.

Research output: Contribution to journalArticle

Korenaga, D, Saito, A, Baba, H, Watanabe, A, Okamura, T, Maehara, Y & Sugimachi, K 1990, 'Cytophotometrically determined DNA content, mitotic activity, and lymph node metastasis in clinical gastric cancer', Surgery, vol. 107, no. 3, pp. 262-267.
Korenaga D, Saito A, Baba H, Watanabe A, Okamura T, Maehara Y et al. Cytophotometrically determined DNA content, mitotic activity, and lymph node metastasis in clinical gastric cancer. Surgery. 1990 Jan 1;107(3):262-267.
Korenaga, D. ; Saito, A. ; Baba, H. ; Watanabe, A. ; Okamura, T. ; Maehara, Yoshihiko ; Sugimachi, K. / Cytophotometrically determined DNA content, mitotic activity, and lymph node metastasis in clinical gastric cancer. In: Surgery. 1990 ; Vol. 107, No. 3. pp. 262-267.
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