Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium

Hiroyuki Tsutsui, Kazuaki Ishihara, George Cooper IV

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Cardiac hypertrophy in response to systolic pressure loading frequently results in contractile dysfunction of unknown cause. In the present study, pressure loading increased the microtubule component of the cardiac muscle cell cytoskeleton, which was responsible for the cellular contractile dysfunction observed. The linked microtubule and contractile abnormalities were persistent and thus may have significance for the deterioration of initially compensatory cardiac hypertrophy into congestive heart failure.

Original languageEnglish
Pages (from-to)682-687
Number of pages6
JournalScience
Volume260
Issue number5108
DOIs
Publication statusPublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • General

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