Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Olivier Placide Noté, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Dieudonné Emmanuel Pegnyemb, Marie Aleth Lacaille-Dubois

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28 Citations (Scopus)

Abstract

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 μM for 1 and 2.7 μM for 3) and HT-29 (IC50 6.7 μM for 1 and 7.9 μM for 3) cell lines.

Original languageEnglish
Pages (from-to)1725-1730
Number of pages6
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - Oct 23 2009

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Noté, O. P., Mitaine-Offer, A. C., Miyamoto, T., Paululat, T., Mirjolet, J. F., Duchamp, O., Pegnyemb, D. E., & Lacaille-Dubois, M. A. (2009). Cytotoxic acacic acid glycosides from the roots of Albizia coriaria. Journal of Natural Products, 72(10), 1725-1730. https://doi.org/10.1021/np900126r