Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Rosalind Pei Theng Kim, Vicky Bihud, Khalit Bin Mohamad, Kok Hoong Leong, Jamaludin Bin Mohamad, Fasihuddin Bin Ahmad, Hazrina Hazni, Noraini Kasim, Siti Nadiah Abdul Halim, Khalijah Awang

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

    Original languageEnglish
    Pages (from-to)128-139
    Number of pages12
    JournalMolecules
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - Jan 2013

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Chemistry (miscellaneous)
    • Molecular Medicine
    • Pharmaceutical Science
    • Drug Discovery
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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