Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Rosalind Pei Theng Kim, Vicky Bihud, Khalit Bin Mohamad, Kok Hoong Leong, Jamaludin Bin Mohamad, Fasihuddin Bin Ahmad, Hazrina Hazni, Noraini Kasim, Siti Nadiah Abdul Halim, Khalijah Awang

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8 Citations (Scopus)

Abstract

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

Original languageEnglish
Pages (from-to)128-139
Number of pages12
JournalMolecules
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Kim, R. P. T., Bihud, V., Bin Mohamad, K., Leong, K. H., Bin Mohamad, J., Bin Ahmad, F., Hazni, H., Kasim, N., Halim, S. N. A., & Awang, K. (2013). Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh. Molecules, 18(1), 128-139. https://doi.org/10.3390/molecules18010128