Cytotoxic lavandulyl flavanones from Sophora flavescens

Tai Hyun Kang, Sei Joon Jeong, Won Gil Ko, Na Young Kim, Byung Hoon Lee, Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Higuchi, Youn Chul Kim

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110 Citations (Scopus)

Abstract

Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (- )-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

Original languageEnglish
Pages (from-to)680-681
Number of pages2
JournalJournal of Natural Products
Volume63
Issue number5
DOIs
Publication statusPublished - May 1 2000

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., Miyamoto, T., Higuchi, R., & Kim, Y. C. (2000). Cytotoxic lavandulyl flavanones from Sophora flavescens. Journal of Natural Products, 63(5), 680-681. https://doi.org/10.1021/np990567x