Cytotoxic lavandulyl flavanones from Sophora flavescens

Tai Hyun Kang, Sei Joon Jeong, Won Gil Ko, Na Young Kim, Byung Hoon Lee, Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Higuchi, Youn Chul Kim

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (- )-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

Original languageEnglish
Pages (from-to)680-681
Number of pages2
JournalJournal of Natural Products
Volume63
Issue number5
DOIs
Publication statusPublished - May 1 2000

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Sophora
Flavanones
Optical rotation
Optical Rotation
Myeloid Leukemia
HL-60 Cells
Human Activities

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., ... Kim, Y. C. (2000). Cytotoxic lavandulyl flavanones from Sophora flavescens. Journal of Natural Products, 63(5), 680-681. https://doi.org/10.1021/np990567x

Cytotoxic lavandulyl flavanones from Sophora flavescens. / Kang, Tai Hyun; Jeong, Sei Joon; Ko, Won Gil; Kim, Na Young; Lee, Byung Hoon; Inagaki, Masanori; Miyamoto, Tomofumi; Higuchi, Ryuichi; Kim, Youn Chul.

In: Journal of Natural Products, Vol. 63, No. 5, 01.05.2000, p. 680-681.

Research output: Contribution to journalArticle

Kang, TH, Jeong, SJ, Ko, WG, Kim, NY, Lee, BH, Inagaki, M, Miyamoto, T, Higuchi, R & Kim, YC 2000, 'Cytotoxic lavandulyl flavanones from Sophora flavescens', Journal of Natural Products, vol. 63, no. 5, pp. 680-681. https://doi.org/10.1021/np990567x
Kang TH, Jeong SJ, Ko WG, Kim NY, Lee BH, Inagaki M et al. Cytotoxic lavandulyl flavanones from Sophora flavescens. Journal of Natural Products. 2000 May 1;63(5):680-681. https://doi.org/10.1021/np990567x
Kang, Tai Hyun ; Jeong, Sei Joon ; Ko, Won Gil ; Kim, Na Young ; Lee, Byung Hoon ; Inagaki, Masanori ; Miyamoto, Tomofumi ; Higuchi, Ryuichi ; Kim, Youn Chul. / Cytotoxic lavandulyl flavanones from Sophora flavescens. In: Journal of Natural Products. 2000 ; Vol. 63, No. 5. pp. 680-681.
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