Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

Debabrata Acharya, Anne Claire Mitaine-Offer, Nutan Kaushik, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

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40 Citations (Scopus)

Abstract

Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Acharya, D., Mitaine-Offer, A. C., Kaushik, N., Miyamoto, T., Paululat, T., Mirjolet, J. F., ... Lacaille-Dubois, M. A. (2009). Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum. Journal of Natural Products, 72(1), 177-181. https://doi.org/10.1021/np800559z