D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light

Haruna Sugahara, Cornelia Meinert, Laurent Nahon, Nykola C. Jones, Søren V. Hoffmann, Kenji Hamase, Yoshinori Takano, Uwe J. Meierhenrich

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Living organisms on the Earth almost exclusively use L-amino acids for the molecular architecture of proteins. The biological occurrence of D-amino acids is rare, although their functions in various organisms are being gradually understood. A possible explanation for the origin of biomolecular homochirality is the delivery of enantioenriched molecules via extraterrestrial bodies, such as asteroids and comets on early Earth. For the asymmetric formation of amino acids and their precursor molecules in interstellar environments, the interaction with circularly polarized photons is considered to have played a potential role in causing chiral asymmetry. In this review, we summarize recent progress in the investigation of chirality transfer from chiral photons to amino acids involving the two major processes of asymmetric photolysis and asymmetric synthesis. We will discuss analytical data on cometary and meteoritic amino acids and their potential impact delivery to the early Earth. The ongoing and future ambitious space missions, Hayabusa2, OSIRIS-REx, ExoMars 2020, and MMX, are scheduled to provide new insights into the chirality of extraterrestrial organic molecules and their potential relation to the terrestrial homochirality. This article is part of a Special Issue entitled: D-Amino acids: biology in the mirror, edited by Dr. Loredano Pollegioni, Dr. Jean-Pierre Mothet and Dr. Molla Gianluca.

Original languageEnglish
Pages (from-to)743-758
Number of pages16
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1866
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Molecular Evolution
Photolysis
Light polarization
Light
Amino Acids
Chirality
Earth (planet)
Photons
Molecules
Minor Planets
Asteroids
Mirrors
Proteins

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light. / Sugahara, Haruna; Meinert, Cornelia; Nahon, Laurent; Jones, Nykola C.; Hoffmann, Søren V.; Hamase, Kenji; Takano, Yoshinori; Meierhenrich, Uwe J.

In: Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1866, No. 7, 01.07.2018, p. 743-758.

Research output: Contribution to journalReview article

Sugahara, Haruna ; Meinert, Cornelia ; Nahon, Laurent ; Jones, Nykola C. ; Hoffmann, Søren V. ; Hamase, Kenji ; Takano, Yoshinori ; Meierhenrich, Uwe J. / D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light. In: Biochimica et Biophysica Acta - Proteins and Proteomics. 2018 ; Vol. 1866, No. 7. pp. 743-758.
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