D-RECS (4) a novel gene carrier responding to intracellular protease signal

Kenji Kawamura, Jun Oishi, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

Research output: Contribution to conferencePaper

Abstract

We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 19 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period5/24/065/26/06

Fingerprint

Genes
Transcription
Gene expression
Cell death
Polymers
Coulomb interactions
Peptides
DNA
Cells
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Kawamura, K., Oishi, J., Ijuin, M., Kang, J. H., Asai, D., Sato, Y., & Katayama, Y. (2006). D-RECS (4) a novel gene carrier responding to intracellular protease signal. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

D-RECS (4) a novel gene carrier responding to intracellular protease signal. / Kawamura, Kenji; Oishi, Jun; Ijuin, Moeko; Kang, Jeong Hun; Asai, Daisuke; Sato, Yuko; Katayama, Yoshiki.

2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

Research output: Contribution to conferencePaper

Kawamura, K, Oishi, J, Ijuin, M, Kang, JH, Asai, D, Sato, Y & Katayama, Y 2006, 'D-RECS (4) a novel gene carrier responding to intracellular protease signal' Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan, 5/24/06 - 5/26/06, .
Kawamura K, Oishi J, Ijuin M, Kang JH, Asai D, Sato Y et al. D-RECS (4) a novel gene carrier responding to intracellular protease signal. 2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.
Kawamura, Kenji ; Oishi, Jun ; Ijuin, Moeko ; Kang, Jeong Hun ; Asai, Daisuke ; Sato, Yuko ; Katayama, Yoshiki. / D-RECS (4) a novel gene carrier responding to intracellular protease signal. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.1 p.
@conference{45f05e8a1b3447539bfdc54e5c55b37c,
title = "D-RECS (4) a novel gene carrier responding to intracellular protease signal",
abstract = "We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.",
author = "Kenji Kawamura and Jun Oishi and Moeko Ijuin and Kang, {Jeong Hun} and Daisuke Asai and Yuko Sato and Yoshiki Katayama",
year = "2006",
month = "10",
day = "19",
language = "English",
note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

}

TY - CONF

T1 - D-RECS (4) a novel gene carrier responding to intracellular protease signal

AU - Kawamura, Kenji

AU - Oishi, Jun

AU - Ijuin, Moeko

AU - Kang, Jeong Hun

AU - Asai, Daisuke

AU - Sato, Yuko

AU - Katayama, Yoshiki

PY - 2006/10/19

Y1 - 2006/10/19

N2 - We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.

AB - We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.

UR - http://www.scopus.com/inward/record.url?scp=33749853333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749853333&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749853333

ER -