Abstract
We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - Oct 19 2006 |
| Event | 55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006 |
Other
| Other | 55th SPSJ Annual Meeting |
|---|---|
| Country | Japan |
| City | Nagoya |
| Period | 5/24/06 → 5/26/06 |
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All Science Journal Classification (ASJC) codes
- Engineering(all)
Cite this
D-RECS (4) a novel gene carrier responding to intracellular protease signal. / Kawamura, Kenji; Oishi, Jun; Ijuin, Moeko; Kang, Jeong Hun; Asai, Daisuke; Sato, Yuko; Katayama, Yoshiki.
2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.Research output: Contribution to conference › Paper
}
TY - CONF
T1 - D-RECS (4) a novel gene carrier responding to intracellular protease signal
AU - Kawamura, Kenji
AU - Oishi, Jun
AU - Ijuin, Moeko
AU - Kang, Jeong Hun
AU - Asai, Daisuke
AU - Sato, Yuko
AU - Katayama, Yoshiki
PY - 2006/10/19
Y1 - 2006/10/19
N2 - We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.
AB - We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.
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M3 - Paper
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