D-RECS (4) a novel gene carrier responding to intracellular protease signal

Kenji Kawamura, Jun Oishi, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.

    Original languageEnglish
    Number of pages1
    Publication statusPublished - Oct 19 2006
    Event55th SPSJ Annual Meeting - Nagoya, Japan
    Duration: May 24 2006May 26 2006

    Other

    Other55th SPSJ Annual Meeting
    Country/TerritoryJapan
    CityNagoya
    Period5/24/065/26/06

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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