TY - JOUR
T1 - Dairy consumption and risk of functional disability in an elderly Japanese population
T2 - The Hisayama Study
AU - Yoshida, Daigo
AU - Ohara, Tomoyuki
AU - Hata, Jun
AU - Shibata, Mao
AU - Hirakawa, Yoichiro
AU - Honda, Takanori
AU - Uchida, Kazuhiro
AU - Takasugi, Satoshi
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
AU - Ninomiya, Toshiharu
N1 - Funding Information:
This study was supported in part by Grants-in-Aid for Scientific Research (A) (JP16H02644 and JP16H02692) and (B) (JP16H05850, JP16H05557, JP17H04126, and JP18H02737) and (C) (JP16K09244, JP17K09114, JP17K09113, JP17K01853, JP18K07565, and JP18K09412) and (Early-Career Scientists) (JP18K17925 and JP18K17382) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; by Health and Labour Sciences Research Grants of the Ministry of Health, Labour, and Welfare of Japan (H29-Junkankitou-Ippan-003 and H30-Shokuhin-[Sitei]-005); and by the Japan Agency for Medical Research and Development (JP18dk0207025, JP18ek0210082, JP18gm0610007, JP18ek0210083, JP18km0405202, JP18ek0210080, and JP18fk0108075). This study was also sponsored by Meiji Co., Ltd.
Publisher Copyright:
© American Society for Nutrition 2019. All rights reserved.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: Little is known about the association between dairy intake and risk of functional disability in the elderly. Objectives: We examined the influence of dairy intake on the development of declining functional capacity and activities of daily living (ADL) in a prospective cohort study of an elderly population. Methods: A total of 859 community-dwelling Japanese residents, aged ?65 y without functional disability, were followed up for 7 y. Functional capacity impairment was defined as a TokyoMetropolitan Institute of Gerontology Index of Competence score of ≥12, and ADL disability was defined as a Barthel Index score of ≥95. Dairy intake was evaluated using a 150-item semiquantitative food frequency questionnaire, grouped into quartiles. The RR of dairy intake on incident functional disabilitywas computed using a Poisson regression model. Results: The multivariable-Adjusted RR of impaired functional capacity decreased significantly with increasing dairy intake levels (RR [95% CI]: quartile 1, 1.00 [reference]; quartile 2, 0.85 [0.71, 1.02]; quartile 3, 0.81 [0.68, 0.98]; and quartile 4, 0.74 [0.61, 0.90]; P-Trend = 0.001). Regarding the three subscales of functional capacity, the inverse association between dairy intake and risk for impairment of intellectual activity and social role remained significant (P-Trend = 0.0009 and 0.02, respectively), but such an association was not observed for instrumental ADL. The multivariable-Adjusted risk of ADL disability also decreased weakly but significantly with elevating dairy intake (P-Trend=0.04). A similar association was seen for severity of functional disability (P-Trend = 0.002). However, the magnitude of these associations was attenuated after further adjustment for protein intake. Conclusion: Our findings suggest that higher dairy intake is associated with a lower risk of functional disability and its progression in the elderly, probably via an increase in protein intake.
AB - Background: Little is known about the association between dairy intake and risk of functional disability in the elderly. Objectives: We examined the influence of dairy intake on the development of declining functional capacity and activities of daily living (ADL) in a prospective cohort study of an elderly population. Methods: A total of 859 community-dwelling Japanese residents, aged ?65 y without functional disability, were followed up for 7 y. Functional capacity impairment was defined as a TokyoMetropolitan Institute of Gerontology Index of Competence score of ≥12, and ADL disability was defined as a Barthel Index score of ≥95. Dairy intake was evaluated using a 150-item semiquantitative food frequency questionnaire, grouped into quartiles. The RR of dairy intake on incident functional disabilitywas computed using a Poisson regression model. Results: The multivariable-Adjusted RR of impaired functional capacity decreased significantly with increasing dairy intake levels (RR [95% CI]: quartile 1, 1.00 [reference]; quartile 2, 0.85 [0.71, 1.02]; quartile 3, 0.81 [0.68, 0.98]; and quartile 4, 0.74 [0.61, 0.90]; P-Trend = 0.001). Regarding the three subscales of functional capacity, the inverse association between dairy intake and risk for impairment of intellectual activity and social role remained significant (P-Trend = 0.0009 and 0.02, respectively), but such an association was not observed for instrumental ADL. The multivariable-Adjusted risk of ADL disability also decreased weakly but significantly with elevating dairy intake (P-Trend=0.04). A similar association was seen for severity of functional disability (P-Trend = 0.002). However, the magnitude of these associations was attenuated after further adjustment for protein intake. Conclusion: Our findings suggest that higher dairy intake is associated with a lower risk of functional disability and its progression in the elderly, probably via an increase in protein intake.
UR - http://www.scopus.com/inward/record.url?scp=85067267524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067267524&partnerID=8YFLogxK
U2 - 10.1093/ajcn/nqz040
DO - 10.1093/ajcn/nqz040
M3 - Article
C2 - 31075788
AN - SCOPUS:85067267524
SN - 0002-9165
VL - 109
SP - 1664
EP - 1671
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 6
ER -