Data processing technique in gas chromatography/time-of-flight mass spectrometry

Tomoko Imasaka, Nami Nakamura, Yuji Sakoda, Satoshi Yamaguchi, Yuka Watanabe-Ezoe, Tomohiro Uchimura, Totaro Imasaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A complete mass spectrum was measured at an acquisition rate of 1 kHz using a femtosecond-multiphoton-ionization time-of-flight mass spectrometer for analyte eluting from a gas chromatograph. A contour-map display, i.e. a two-dimensional plot, of the data was first constructed for a simultaneous overview of the mass spectra and the mass chromatograms. The noise component in the signal was then reduced by digital filtering and reduced further by smoothing the data. The detection limit (S/N = 3) was improved from 240 to 76 fg for 2,3,4,6,7-pentachlorodibenzofuran, with no appreciable loss of resolution in the chromatogram. The achieved value was lower than the value (<100 fg) required by Japanese Industrial Standards for dioxin analysis. A new parameter, referred to as a 'reliability factor', was defined in this study to calculate the similarity between the intensity distribution of the isotope peaks observed in the mass spectrum and that calculated from the natural abundance ratio of the isotopes. This parameter was useful for evaluation of the purity of the chromatographic peak.

Original languageEnglish
Pages (from-to)712-718
Number of pages7
JournalAnalyst
Volume134
Issue number4
DOIs
Publication statusPublished - Jun 19 2009

Fingerprint

Isotopes
Gas chromatography
Gas Chromatography
Mass spectrometry
Mass Spectrometry
gas chromatography
mass spectrometry
Dioxins
Mass spectrometers
Ionization
Noise
Limit of Detection
Gases
Display devices
isotope
contour map
smoothing
dioxin
ionization
spectrometer

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this

Imasaka, T., Nakamura, N., Sakoda, Y., Yamaguchi, S., Watanabe-Ezoe, Y., Uchimura, T., & Imasaka, T. (2009). Data processing technique in gas chromatography/time-of-flight mass spectrometry. Analyst, 134(4), 712-718. https://doi.org/10.1039/b815630a

Data processing technique in gas chromatography/time-of-flight mass spectrometry. / Imasaka, Tomoko; Nakamura, Nami; Sakoda, Yuji; Yamaguchi, Satoshi; Watanabe-Ezoe, Yuka; Uchimura, Tomohiro; Imasaka, Totaro.

In: Analyst, Vol. 134, No. 4, 19.06.2009, p. 712-718.

Research output: Contribution to journalArticle

Imasaka, T, Nakamura, N, Sakoda, Y, Yamaguchi, S, Watanabe-Ezoe, Y, Uchimura, T & Imasaka, T 2009, 'Data processing technique in gas chromatography/time-of-flight mass spectrometry', Analyst, vol. 134, no. 4, pp. 712-718. https://doi.org/10.1039/b815630a
Imasaka T, Nakamura N, Sakoda Y, Yamaguchi S, Watanabe-Ezoe Y, Uchimura T et al. Data processing technique in gas chromatography/time-of-flight mass spectrometry. Analyst. 2009 Jun 19;134(4):712-718. https://doi.org/10.1039/b815630a
Imasaka, Tomoko ; Nakamura, Nami ; Sakoda, Yuji ; Yamaguchi, Satoshi ; Watanabe-Ezoe, Yuka ; Uchimura, Tomohiro ; Imasaka, Totaro. / Data processing technique in gas chromatography/time-of-flight mass spectrometry. In: Analyst. 2009 ; Vol. 134, No. 4. pp. 712-718.
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