De novo malignancy after pancreas transplantation in Japan

Y. Tomimaru, T. Ito, S. Marubashi, K. Kawamoto, A. Tomokuni, T. Asaoka, H. Wada, Hidetoshi Eguchi, Masaki Mori, Y. Doki, H. Nagano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.

Original languageEnglish
Pages (from-to)742-745
Number of pages4
JournalTransplantation Proceedings
Volume47
Issue number3
DOIs
Publication statusPublished - Apr 1 2015
Externally publishedYes

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Pancreas Transplantation
Japan
Neoplasms
Transplants
Immunosuppression
Lymphoproliferative Disorders
Kidney Neoplasms
Incidence
Organ Transplantation
Brain Neoplasms
Colonic Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

Tomimaru, Y., Ito, T., Marubashi, S., Kawamoto, K., Tomokuni, A., Asaoka, T., ... Nagano, H. (2015). De novo malignancy after pancreas transplantation in Japan. Transplantation Proceedings, 47(3), 742-745. https://doi.org/10.1016/j.transproceed.2014.11.052

De novo malignancy after pancreas transplantation in Japan. / Tomimaru, Y.; Ito, T.; Marubashi, S.; Kawamoto, K.; Tomokuni, A.; Asaoka, T.; Wada, H.; Eguchi, Hidetoshi; Mori, Masaki; Doki, Y.; Nagano, H.

In: Transplantation Proceedings, Vol. 47, No. 3, 01.04.2015, p. 742-745.

Research output: Contribution to journalArticle

Tomimaru, Y, Ito, T, Marubashi, S, Kawamoto, K, Tomokuni, A, Asaoka, T, Wada, H, Eguchi, H, Mori, M, Doki, Y & Nagano, H 2015, 'De novo malignancy after pancreas transplantation in Japan', Transplantation Proceedings, vol. 47, no. 3, pp. 742-745. https://doi.org/10.1016/j.transproceed.2014.11.052
Tomimaru Y, Ito T, Marubashi S, Kawamoto K, Tomokuni A, Asaoka T et al. De novo malignancy after pancreas transplantation in Japan. Transplantation Proceedings. 2015 Apr 1;47(3):742-745. https://doi.org/10.1016/j.transproceed.2014.11.052
Tomimaru, Y. ; Ito, T. ; Marubashi, S. ; Kawamoto, K. ; Tomokuni, A. ; Asaoka, T. ; Wada, H. ; Eguchi, Hidetoshi ; Mori, Masaki ; Doki, Y. ; Nagano, H. / De novo malignancy after pancreas transplantation in Japan. In: Transplantation Proceedings. 2015 ; Vol. 47, No. 3. pp. 742-745.
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AU - Tomimaru, Y.

AU - Ito, T.

AU - Marubashi, S.

AU - Kawamoto, K.

AU - Tomokuni, A.

AU - Asaoka, T.

AU - Wada, H.

AU - Eguchi, Hidetoshi

AU - Mori, Masaki

AU - Doki, Y.

AU - Nagano, H.

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N2 - Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.

AB - Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.

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