TY - JOUR
T1 - De novo malignancy after pancreas transplantation in Japan
AU - Tomimaru, Y.
AU - Ito, T.
AU - Marubashi, S.
AU - Kawamoto, K.
AU - Tomokuni, A.
AU - Asaoka, T.
AU - Wada, H.
AU - Eguchi, H.
AU - Mori, M.
AU - Doki, Y.
AU - Nagano, H.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
AB - Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
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U2 - 10.1016/j.transproceed.2014.11.052
DO - 10.1016/j.transproceed.2014.11.052
M3 - Article
C2 - 25891723
AN - SCOPUS:84928318753
VL - 47
SP - 742
EP - 745
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 3
ER -
