Abstract
Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
| Original language | English |
|---|---|
| Pages (from-to) | 742-745 |
| Number of pages | 4 |
| Journal | Transplantation Proceedings |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 1 2015 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
- Transplantation
- Medicine(all)
Cite this
De novo malignancy after pancreas transplantation in Japan. / Tomimaru, Y.; Ito, T.; Marubashi, S.; Kawamoto, K.; Tomokuni, A.; Asaoka, T.; Wada, H.; Eguchi, Hidetoshi; Mori, Masaki; Doki, Y.; Nagano, H.
In: Transplantation Proceedings, Vol. 47, No. 3, 01.04.2015, p. 742-745.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - De novo malignancy after pancreas transplantation in Japan
AU - Tomimaru, Y.
AU - Ito, T.
AU - Marubashi, S.
AU - Kawamoto, K.
AU - Tomokuni, A.
AU - Asaoka, T.
AU - Wada, H.
AU - Eguchi, Hidetoshi
AU - Mori, Masaki
AU - Doki, Y.
AU - Nagano, H.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
AB - Background Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Methods Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Results Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. Conclusions We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
UR - http://www.scopus.com/inward/record.url?scp=84928318753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928318753&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2014.11.052
DO - 10.1016/j.transproceed.2014.11.052
M3 - Article
C2 - 25891723
AN - SCOPUS:84928318753
VL - 47
SP - 742
EP - 745
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 3
ER -