Death attributed to amobarbital and levomepromazine intoxication

Yukiko Hino, Noriaki Ikeda, Keiko Kudo, Akiko Tsuji, Seiya Sannohe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 29-year-old man, possibly a schizophrenic patient, was found dead 9 h after admission to a hospital. Autopsy revealed neither significant injuries nor diseases except for congestion of all organs. Microscopic examination revealed severe edema in the lung and slight centrilobular necrosis in the liver. Since amobarbital and levomepromazine were detected by drug screening, the concentrations of these drugs in the victim's body fluids and tissues were determined using gas chromatography-mass spectrometry. The whole blood concentrations of amobarbital and levomepromazine were 9.02 μg/ml and 231 ng/ml, respectively. These levels exceeded therapeutic ranges, but are not so toxic or fatal. However, on the basis of the findings in the literature and of the severe lung edema and centrilobular necrosis in the liver, the cause of his death was judged to be amobarbital and levomepromazine intoxication.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalLegal Medicine
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

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Methotrimeprazine
Amobarbital
Edema
Necrosis
Lung
Preclinical Drug Evaluations
Poisons
Liver
Body Fluids
Gas Chromatography-Mass Spectrometry
Cause of Death
Autopsy
Wounds and Injuries
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects

Cite this

Death attributed to amobarbital and levomepromazine intoxication. / Hino, Yukiko; Ikeda, Noriaki; Kudo, Keiko; Tsuji, Akiko; Sannohe, Seiya.

In: Legal Medicine, Vol. 1, No. 1, 01.01.1999, p. 48-51.

Research output: Contribution to journalArticle

Hino, Yukiko ; Ikeda, Noriaki ; Kudo, Keiko ; Tsuji, Akiko ; Sannohe, Seiya. / Death attributed to amobarbital and levomepromazine intoxication. In: Legal Medicine. 1999 ; Vol. 1, No. 1. pp. 48-51.
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