Decay of linkage disequilibrium in a finite island model

Hidenori Tachida

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Time-dependent behaviour of linkage disequilibrium when there was initial linkage disequilibrium is studied in a finite island model assuming neutrality. Explicit expressions for linkage disequilibrium parameters are obtained. From these expressions, the initial and the ultimate decay rates of linkage disequilibrium parameters are found to be increased and decreased, respectively, by finiteness of the population when recombination rate, migration rate and inverse of subpopulation size are of comparable order. Thus, linkage disequilibrium created in the past may persist longerin smaller subdivided populations. Also, differentiation of the gametic parameter of linkage disequilibrium among subpopulations is found to diminish quickly compared tothe linkage disequilibrium in the whole population. Implications of these results for the interpretation of linkage disequilibria in natural populations are discussed.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalGenetical Research
Volume64
Issue number2
DOIs
Publication statusPublished - 1994

Fingerprint

Linkage Disequilibrium
Islands
Population
Genetic Recombination

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Decay of linkage disequilibrium in a finite island model. / Tachida, Hidenori.

In: Genetical Research, Vol. 64, No. 2, 1994, p. 137-144.

Research output: Contribution to journalArticle

Tachida, Hidenori. / Decay of linkage disequilibrium in a finite island model. In: Genetical Research. 1994 ; Vol. 64, No. 2. pp. 137-144.
@article{84d1394d9c544a6bbe7b912baa1de1e1,
title = "Decay of linkage disequilibrium in a finite island model",
abstract = "Time-dependent behaviour of linkage disequilibrium when there was initial linkage disequilibrium is studied in a finite island model assuming neutrality. Explicit expressions for linkage disequilibrium parameters are obtained. From these expressions, the initial and the ultimate decay rates of linkage disequilibrium parameters are found to be increased and decreased, respectively, by finiteness of the population when recombination rate, migration rate and inverse of subpopulation size are of comparable order. Thus, linkage disequilibrium created in the past may persist longerin smaller subdivided populations. Also, differentiation of the gametic parameter of linkage disequilibrium among subpopulations is found to diminish quickly compared tothe linkage disequilibrium in the whole population. Implications of these results for the interpretation of linkage disequilibria in natural populations are discussed.",
author = "Hidenori Tachida",
year = "1994",
doi = "10.1017/S0016672300032742",
language = "English",
volume = "64",
pages = "137--144",
journal = "Genetical Research",
issn = "0016-6723",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - Decay of linkage disequilibrium in a finite island model

AU - Tachida, Hidenori

PY - 1994

Y1 - 1994

N2 - Time-dependent behaviour of linkage disequilibrium when there was initial linkage disequilibrium is studied in a finite island model assuming neutrality. Explicit expressions for linkage disequilibrium parameters are obtained. From these expressions, the initial and the ultimate decay rates of linkage disequilibrium parameters are found to be increased and decreased, respectively, by finiteness of the population when recombination rate, migration rate and inverse of subpopulation size are of comparable order. Thus, linkage disequilibrium created in the past may persist longerin smaller subdivided populations. Also, differentiation of the gametic parameter of linkage disequilibrium among subpopulations is found to diminish quickly compared tothe linkage disequilibrium in the whole population. Implications of these results for the interpretation of linkage disequilibria in natural populations are discussed.

AB - Time-dependent behaviour of linkage disequilibrium when there was initial linkage disequilibrium is studied in a finite island model assuming neutrality. Explicit expressions for linkage disequilibrium parameters are obtained. From these expressions, the initial and the ultimate decay rates of linkage disequilibrium parameters are found to be increased and decreased, respectively, by finiteness of the population when recombination rate, migration rate and inverse of subpopulation size are of comparable order. Thus, linkage disequilibrium created in the past may persist longerin smaller subdivided populations. Also, differentiation of the gametic parameter of linkage disequilibrium among subpopulations is found to diminish quickly compared tothe linkage disequilibrium in the whole population. Implications of these results for the interpretation of linkage disequilibria in natural populations are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0027986930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027986930&partnerID=8YFLogxK

U2 - 10.1017/S0016672300032742

DO - 10.1017/S0016672300032742

M3 - Article

VL - 64

SP - 137

EP - 144

JO - Genetical Research

JF - Genetical Research

SN - 0016-6723

IS - 2

ER -