Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry

Hiroaki Shigemura, Mari Matsui, Tsuyoshi Sekizuka, Daisuke Onozuka, Tamie Noda, Akifumi Yamashita, Makoto Kuroda, Satowa Suzuki, Hirokazu Kimura, Shuji Fujimoto, Kazunori Oishi, Nobuyuki Sera, Yasuo Inoshima, Koichi Murakami

Research output: Contribution to journalArticle

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Abstract

Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. We previously reported that the prevalence of ESC-resistant Salmonella in chicken meat, giblets, and processed chicken (chicken meat products) increased in Japan between 2005 and 2010, with 27.9% (17/61) of Salmonella isolated from chicken meat products in 2010 showing resistance to ESC. The aims of the present study were to clarify trends in the prevalence of ESC-resistant Salmonella in chicken meat products in Japan between 2011 and 2015, and to determine the genetic profiles of bla-harboring plasmids, including replicon types, using next-generation sequencing. Our results showed that the prevalence of ESC-resistant Salmonella, mainly consisting of AmpC β-lactamase CMY-2-producing isolates, in chicken meat products had increased to 45.5% (10/22) by 2011. However, following the voluntary cessation of ceftiofur use by the Japanese poultry industry in 2012, the prevalence of ESC-resistant Salmonella steadily decreased each year, to 29.2% (7/24), 18.2% (4/22), 10.5% (2/19), and 10.5% (2/19) in 2012, 2013, 2014, and 2015, respectively. Furthermore, no AmpC β-lactamase CMY-2-producing isolates were identified in 2014 and 2015. However, the prevalence of Salmonella enterica subspecies enterica serovar Manhattan isolates harboring a blaTEM-52-carrying IncX1 plasmid remained steady even after the cessation of ceftiofur use. Therefore, continuous monitoring of ESC resistance amongst Salmonella isolates from chicken meat products is required for food safety.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalInternational Journal of Food Microbiology
Volume274
DOIs
Publication statusPublished - Jun 2 2018

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ceftiofur
cephalosporins
poultry industry
chicken meat
Cephalosporins
Poultry
Salmonella
Chickens
Industry
Meat Products
meat products
Food Safety
food safety
plasmids
Meat
giblets
Japan
Plasmids
Cephalosporin Resistance
replicon

All Science Journal Classification (ASJC) codes

  • Food Science
  • Microbiology

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Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry. / Shigemura, Hiroaki; Matsui, Mari; Sekizuka, Tsuyoshi; Onozuka, Daisuke; Noda, Tamie; Yamashita, Akifumi; Kuroda, Makoto; Suzuki, Satowa; Kimura, Hirokazu; Fujimoto, Shuji; Oishi, Kazunori; Sera, Nobuyuki; Inoshima, Yasuo; Murakami, Koichi.

In: International Journal of Food Microbiology, Vol. 274, 02.06.2018, p. 45-51.

Research output: Contribution to journalArticle

Shigemura, H, Matsui, M, Sekizuka, T, Onozuka, D, Noda, T, Yamashita, A, Kuroda, M, Suzuki, S, Kimura, H, Fujimoto, S, Oishi, K, Sera, N, Inoshima, Y & Murakami, K 2018, 'Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry', International Journal of Food Microbiology, vol. 274, pp. 45-51. https://doi.org/10.1016/j.ijfoodmicro.2018.03.011
Shigemura, Hiroaki ; Matsui, Mari ; Sekizuka, Tsuyoshi ; Onozuka, Daisuke ; Noda, Tamie ; Yamashita, Akifumi ; Kuroda, Makoto ; Suzuki, Satowa ; Kimura, Hirokazu ; Fujimoto, Shuji ; Oishi, Kazunori ; Sera, Nobuyuki ; Inoshima, Yasuo ; Murakami, Koichi. / Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry. In: International Journal of Food Microbiology. 2018 ; Vol. 274. pp. 45-51.
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abstract = "Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. We previously reported that the prevalence of ESC-resistant Salmonella in chicken meat, giblets, and processed chicken (chicken meat products) increased in Japan between 2005 and 2010, with 27.9{\%} (17/61) of Salmonella isolated from chicken meat products in 2010 showing resistance to ESC. The aims of the present study were to clarify trends in the prevalence of ESC-resistant Salmonella in chicken meat products in Japan between 2011 and 2015, and to determine the genetic profiles of bla-harboring plasmids, including replicon types, using next-generation sequencing. Our results showed that the prevalence of ESC-resistant Salmonella, mainly consisting of AmpC β-lactamase CMY-2-producing isolates, in chicken meat products had increased to 45.5{\%} (10/22) by 2011. However, following the voluntary cessation of ceftiofur use by the Japanese poultry industry in 2012, the prevalence of ESC-resistant Salmonella steadily decreased each year, to 29.2{\%} (7/24), 18.2{\%} (4/22), 10.5{\%} (2/19), and 10.5{\%} (2/19) in 2012, 2013, 2014, and 2015, respectively. Furthermore, no AmpC β-lactamase CMY-2-producing isolates were identified in 2014 and 2015. However, the prevalence of Salmonella enterica subspecies enterica serovar Manhattan isolates harboring a blaTEM-52-carrying IncX1 plasmid remained steady even after the cessation of ceftiofur use. Therefore, continuous monitoring of ESC resistance amongst Salmonella isolates from chicken meat products is required for food safety.",
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AU - Matsui, Mari

AU - Sekizuka, Tsuyoshi

AU - Onozuka, Daisuke

AU - Noda, Tamie

AU - Yamashita, Akifumi

AU - Kuroda, Makoto

AU - Suzuki, Satowa

AU - Kimura, Hirokazu

AU - Fujimoto, Shuji

AU - Oishi, Kazunori

AU - Sera, Nobuyuki

AU - Inoshima, Yasuo

AU - Murakami, Koichi

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