DECREASED EXPRESSION OF THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR mRNA IN THE CARDIAC VENTRICLE OF SPONTANEOUSLY HYPERTENSIVE RATS

H. Jingami, H. Masuzaki, N. Matsuoka, O. Nakagawa, Yoshihiro Ogawa, M. Mizuno, T. Yamamoto, K. Nakao

Research output: Contribution to journalArticle

Abstract

1. To elucidate the functional implication of very low density lipoprotein (VLDL) receptor, we studied the gene expression of VLDL receptor in rats. The VLDL receptor mRNA was highly expressed in the cardiac ventricle and skeletal muscle. Intermediate amounts of VLDL receptor mRNA were detected in adipose tissue, adrenal gland, brain and lung. Thus the tissue distribution of VLDL receptor mRNA in rats was similar to that reported previously in rabbits. 2. We studied the gene expression of the VLDL receptor in the heart of stroke‐prone spontaneously hypertensive rats (SHRSP), an animal model for hypertension‐induced cardiac hypertrophy. RNase protection assay showed that the level of ventricular VLDL receptor mRNA was already decreased to one half when hypertension was not fully developed, and further diminished to one fifth when cardiac hypertrophy was established. 3. It is reported that energy utilization in SHRSP hypertrophied myocardium is impaired. Our results suggest that inactive fatty acid metabolism in the ventricle of SHRSP is related to the lowered expression of the VLDL receptor which is postulated as a gate for triglyceride‐rich lipoprotein particle.

Original languageEnglish
Pages (from-to)S246-S248
JournalClinical and Experimental Pharmacology and Physiology
Volume22
DOIs
Publication statusPublished - Jan 1 1995

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Inbred SHR Rats
Heart Ventricles
Messenger RNA
Cardiomegaly
Myocardium
Gene Expression
VLDL receptor
Tissue Distribution
Ribonucleases
Adrenal Glands
Lipoproteins
Adipose Tissue
Skeletal Muscle
Fatty Acids
Animal Models
Rabbits
Hypertension
Lung
Brain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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DECREASED EXPRESSION OF THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR mRNA IN THE CARDIAC VENTRICLE OF SPONTANEOUSLY HYPERTENSIVE RATS. / Jingami, H.; Masuzaki, H.; Matsuoka, N.; Nakagawa, O.; Ogawa, Yoshihiro; Mizuno, M.; Yamamoto, T.; Nakao, K.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 22, 01.01.1995, p. S246-S248.

Research output: Contribution to journalArticle

Jingami, H. ; Masuzaki, H. ; Matsuoka, N. ; Nakagawa, O. ; Ogawa, Yoshihiro ; Mizuno, M. ; Yamamoto, T. ; Nakao, K. / DECREASED EXPRESSION OF THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR mRNA IN THE CARDIAC VENTRICLE OF SPONTANEOUSLY HYPERTENSIVE RATS. In: Clinical and Experimental Pharmacology and Physiology. 1995 ; Vol. 22. pp. S246-S248.
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abstract = "1. To elucidate the functional implication of very low density lipoprotein (VLDL) receptor, we studied the gene expression of VLDL receptor in rats. The VLDL receptor mRNA was highly expressed in the cardiac ventricle and skeletal muscle. Intermediate amounts of VLDL receptor mRNA were detected in adipose tissue, adrenal gland, brain and lung. Thus the tissue distribution of VLDL receptor mRNA in rats was similar to that reported previously in rabbits. 2. We studied the gene expression of the VLDL receptor in the heart of stroke‐prone spontaneously hypertensive rats (SHRSP), an animal model for hypertension‐induced cardiac hypertrophy. RNase protection assay showed that the level of ventricular VLDL receptor mRNA was already decreased to one half when hypertension was not fully developed, and further diminished to one fifth when cardiac hypertrophy was established. 3. It is reported that energy utilization in SHRSP hypertrophied myocardium is impaired. Our results suggest that inactive fatty acid metabolism in the ventricle of SHRSP is related to the lowered expression of the VLDL receptor which is postulated as a gate for triglyceride‐rich lipoprotein particle.",
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AU - Masuzaki, H.

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