Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: Report from the Hokkaido acute myocardial infarction registry

Hiroki Satoh, Naoki Ishimori, Mamoru Sakakibara, Shiro Yamada, Nozomu Kawashima, Kazushi Urasawa, Satoshi Fujii, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

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Abstract

Renal dysfunction is a significant risk factor in the prognosis of patients with cardiovascular diseases. We sought to determine the relationship between estimated glomerular filtration rate (eGFR) values and in-hospital mortality in Japanese acute myocardial infarction (AMI) patients. A total of 2266 consecutive AMI patients admitted to 22 hospitals in Hokkaido were registered. The eGFR values were determined using the following equation: eGFR=194 × (serum creatinine) -1.094 × (age) -0.287 ( × 0.739 if female). Patients were classified into four groups according to their eGFR values: ≥60 (n=1304), 30-59 (n=810), 15-29 (n=87) and <15 ml min -1 per 1.73 m 2 (n=65). A total of 110 patients (4.9%) died during hospitalization. The in-hospital mortality rate was significantly higher in patients with reduced eGFR values at 2.3, 5.4, 24.1 and 23.1% for eGFR values of ≥60, 30-59, 15-29, and <15 ml min -1 per 1.73 m 2 , respectively. The odds ratios for in-hospital all cause death were 8.26 (95% confidence interval (CI): 2.22-30.77) for eGFR<15 ml min -1 per 1.73 m 2 and 3.42 (95% CI: 1.01-11.61) for eGFR 15-29 ml min -1 per 1.73 m 2 compared with eGFR ≥60 ml min -1 per 1.73 m 2 . Similarly, the odds ratios for in-hospital cardiac death were 8.43 (95% CI: 1.82-39.05) for eGFR<15 ml min -1 per 1.73 m 2 and 5.47 (95% CI: 1.51-19.80) for eGFR 15-29 ml min -1 per 1.73 m 2 . In conclusion, the eGFR of <30 ml min -1 per 1.73 m 2 was a significant and independent risk for in-hospital mortality in abroad cohort of Japanese patients with AMI.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalHypertension Research
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 1 2012
Externally publishedYes

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Hospital Mortality
Glomerular Filtration Rate
Registries
Myocardial Infarction
Confidence Intervals
Odds Ratio
Cause of Death
Creatinine
Hospitalization
Cardiovascular Diseases
Kidney

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction : Report from the Hokkaido acute myocardial infarction registry. / Satoh, Hiroki; Ishimori, Naoki; Sakakibara, Mamoru; Yamada, Shiro; Kawashima, Nozomu; Urasawa, Kazushi; Fujii, Satoshi; Tsutsui, Hiroyuki.

In: Hypertension Research, Vol. 35, No. 4, 01.04.2012, p. 463-469.

Research output: Contribution to journalArticle

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abstract = "Renal dysfunction is a significant risk factor in the prognosis of patients with cardiovascular diseases. We sought to determine the relationship between estimated glomerular filtration rate (eGFR) values and in-hospital mortality in Japanese acute myocardial infarction (AMI) patients. A total of 2266 consecutive AMI patients admitted to 22 hospitals in Hokkaido were registered. The eGFR values were determined using the following equation: eGFR=194 × (serum creatinine) -1.094 × (age) -0.287 ( × 0.739 if female). Patients were classified into four groups according to their eGFR values: ≥60 (n=1304), 30-59 (n=810), 15-29 (n=87) and <15 ml min -1 per 1.73 m 2 (n=65). A total of 110 patients (4.9{\%}) died during hospitalization. The in-hospital mortality rate was significantly higher in patients with reduced eGFR values at 2.3, 5.4, 24.1 and 23.1{\%} for eGFR values of ≥60, 30-59, 15-29, and <15 ml min -1 per 1.73 m 2 , respectively. The odds ratios for in-hospital all cause death were 8.26 (95{\%} confidence interval (CI): 2.22-30.77) for eGFR<15 ml min -1 per 1.73 m 2 and 3.42 (95{\%} CI: 1.01-11.61) for eGFR 15-29 ml min -1 per 1.73 m 2 compared with eGFR ≥60 ml min -1 per 1.73 m 2 . Similarly, the odds ratios for in-hospital cardiac death were 8.43 (95{\%} CI: 1.82-39.05) for eGFR<15 ml min -1 per 1.73 m 2 and 5.47 (95{\%} CI: 1.51-19.80) for eGFR 15-29 ml min -1 per 1.73 m 2 . In conclusion, the eGFR of <30 ml min -1 per 1.73 m 2 was a significant and independent risk for in-hospital mortality in abroad cohort of Japanese patients with AMI.",
author = "Hiroki Satoh and Naoki Ishimori and Mamoru Sakakibara and Shiro Yamada and Nozomu Kawashima and Kazushi Urasawa and Satoshi Fujii and Hiroyuki Tsutsui",
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T1 - Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction

T2 - Report from the Hokkaido acute myocardial infarction registry

AU - Satoh, Hiroki

AU - Ishimori, Naoki

AU - Sakakibara, Mamoru

AU - Yamada, Shiro

AU - Kawashima, Nozomu

AU - Urasawa, Kazushi

AU - Fujii, Satoshi

AU - Tsutsui, Hiroyuki

PY - 2012/4/1

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