Decreased hindquarters venous distensibility during high salt intake in stroke-prone spontaneously hypertensive rats

Toshiaki Ashihara, Akira Takeshita, Tsutomu Imaizumi, Kunihiko Yamamoto, Sumio Hoka, Motoomi Nakamura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study was done to examine whether high salt intake decreases venous distensibility in stroke-prone spontaneously hypertensive rats (SHR-sp). Ten weeks old male SHR-sp and normotensive Wistar-Kyoto rats (WKY) were fed either high (8 % or normal (0.3 % salt diet for 3 weeks. The hindquarters venous pressure-volume curves were obtained by infusing Krebs-Henseleit solution retrograde into the inferior vena cava at a rate of 12 or 2.1 ml/min. After 3 weeks of dietary treatment, high salt intake shifted the venous pressure-volume curves at maximal venodilatation caused by nitroprusside toward the pressure axis in SHR-sp but not in WKY. The venous pressure-volume curve during interruption of infusion was also shifted toward the pressure axis in SHR-sp on high salt diet as compared with that in SHR-sp on normal salt diet. Water content and thickness of the smooth

Original languageEnglish
Pages (from-to)59-78
Number of pages20
JournalClinical and Experimental Hypertension
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 1988

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Inbred SHR Rats
Salts
Stroke
Venous Pressure
Inbred WKY Rats
Diet
Pressure
Inferior Vena Cava
Nitroprusside
Water

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

Cite this

Decreased hindquarters venous distensibility during high salt intake in stroke-prone spontaneously hypertensive rats. / Ashihara, Toshiaki; Takeshita, Akira; Imaizumi, Tsutomu; Yamamoto, Kunihiko; Hoka, Sumio; Nakamura, Motoomi.

In: Clinical and Experimental Hypertension, Vol. 10, No. 1, 01.01.1988, p. 59-78.

Research output: Contribution to journalArticle

Ashihara, Toshiaki ; Takeshita, Akira ; Imaizumi, Tsutomu ; Yamamoto, Kunihiko ; Hoka, Sumio ; Nakamura, Motoomi. / Decreased hindquarters venous distensibility during high salt intake in stroke-prone spontaneously hypertensive rats. In: Clinical and Experimental Hypertension. 1988 ; Vol. 10, No. 1. pp. 59-78.
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