Decreased hindquarters venous distensibility during high salt intake in stroke-prone spontaneously hypertensive rats

Toshiaki Ashihara, Akira Takeshita, Tsutomu Imaizumi, Kunihiko Yamamoto, Sumio Hoka, Motoomi Nakamura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study was done to examine whether high salt intake decreases venous distensibility in stroke-prone spontaneously hypertensive rats (SHR-sp). Ten weeks old male SHR-sp and normotensive Wistar-Kyoto rats (WKY) were fed either high (8 % or normal (0.3 % salt diet for 3 weeks. The hindquarters venous pressure-volume curves were obtained by infusing Krebs-Henseleit solution retrograde into the inferior vena cava at a rate of 12 or 2.1 ml/min. After 3 weeks of dietary treatment, high salt intake shifted the venous pressure-volume curves at maximal venodilatation caused by nitroprusside toward the pressure axis in SHR-sp but not in WKY. The venous pressure-volume curve during interruption of infusion was also shifted toward the pressure axis in SHR-sp on high salt diet as compared with that in SHR-sp on normal salt diet. Water content and thickness of the smooth

Original languageEnglish
Pages (from-to)59-78
Number of pages20
JournalClinical and Experimental Hypertension
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

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