Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma

Shinichi Aishima, Tomohiro Iguchi, Yunosuke Nishihara, nobuhiro fujita, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

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Abstract

Aims: To assess the relationship between arterial blood supply and the progression of intrahepatic cholangiocarcinoma (ICC). Methods and results: The intratumoral arterial vessel density (AVD) was assessed in 76 cases of mass-forming type of ICC using anti-h-caldesmon antibody, a marker of smooth muscle cells, and AVD compared with pathological findings. AVD was directly correlated with the presence of intratumoral portal tracts (P < 0.0001) and inversely correlated with the grade of tumour necrosis (P = 0.0013). AVD was inversely correlated with vascular invasion and lymph node metastasis (P = 0.0159 and P = 0.0023, respectively). The hilar type of ICC had lower AVD regardless of tumour size, whereas the peripheral type with high AVD showed branching ductular formation composed of cuboidal cells with mild nuclear atypia. AVD was found to be an independent prognostic factor on multivariate survival analysis (P = 0.0013). Conclusions: This study demonstrates that intratumoral arterial vessels reflect engulfed portal tracts in ICC and decreased arterial vessels indicate aggressive tumour behaviour. Our results could contribute to clinical tumour staging and more effective therapy.

Original languageEnglish
Pages (from-to)452-461
Number of pages10
JournalHistopathology
Volume54
Issue number4
DOIs
Publication statusPublished - Mar 1 2009

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Cholangiocarcinoma
Arteries
Klatskin Tumor
Calmodulin-Binding Proteins
Neoplasms
Neoplasm Staging
Survival Analysis
Smooth Muscle Myocytes
Blood Vessels
Necrosis
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Antibodies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. / Aishima, Shinichi; Iguchi, Tomohiro; Nishihara, Yunosuke; fujita, nobuhiro; Taguchi, Kenichi; Taketomi, Akinobu; Maehara, Yoshihiko; Tsuneyoshi, Masazumi.

In: Histopathology, Vol. 54, No. 4, 01.03.2009, p. 452-461.

Research output: Contribution to journalArticle

Aishima, S, Iguchi, T, Nishihara, Y, fujita, N, Taguchi, K, Taketomi, A, Maehara, Y & Tsuneyoshi, M 2009, 'Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma', Histopathology, vol. 54, no. 4, pp. 452-461. https://doi.org/10.1111/j.1365-2559.2009.03240.x
Aishima, Shinichi ; Iguchi, Tomohiro ; Nishihara, Yunosuke ; fujita, nobuhiro ; Taguchi, Kenichi ; Taketomi, Akinobu ; Maehara, Yoshihiko ; Tsuneyoshi, Masazumi. / Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. In: Histopathology. 2009 ; Vol. 54, No. 4. pp. 452-461.
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