Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi; Takao Shimazoe; Seiko Nagata; Takahiro Moriya; Miyuki Maetani; Shigenobu Shibata; Shigenori Watanabe; Kyoko Miyasaka; Akira Kono; Akihiro Funakoshi

doi:10.1016/S0304-3940(97)00324-8

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Neuroscience Letters
Volume	227
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(97)00324-8
Publication status	Published - May 16 1997

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Neuroscience(all)

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10.1016/S0304-3940(97)00324-8

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Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats. / Yamanouchi, Shiro; Shimazoe, Takao; Nagata, Seiko; Moriya, Takahiro; Maetani, Miyuki; Shibata, Shigenobu; Watanabe, Shigenori; Miyasaka, Kyoko; Kono, Akira; Funakoshi, Akihiro.

In: Neuroscience Letters, Vol. 227, No. 2, 16.05.1997, p. 103-106.

Research output: Contribution to journal › Article › peer-review

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abstract = "We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).",

author = "Shiro Yamanouchi and Takao Shimazoe and Seiko Nagata and Takahiro Moriya and Miyuki Maetani and Shigenobu Shibata and Shigenori Watanabe and Kyoko Miyasaka and Akira Kono and Akihiro Funakoshi",

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AU - Moriya, Takahiro

AU - Maetani, Miyuki

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

AU - Miyasaka, Kyoko

AU - Kono, Akira

AU - Funakoshi, Akihiro

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N2 - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

AB - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

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Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Abstract

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