TY - JOUR
T1 - Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats
AU - Yamanouchi, Shiro
AU - Shimazoe, Takao
AU - Nagata, Seiko
AU - Moriya, Takahiro
AU - Maetani, Miyuki
AU - Shibata, Shigenobu
AU - Watanabe, Shigenori
AU - Miyasaka, Kyoko
AU - Kono, Akira
AU - Funakoshi, Akihiro
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1997/5/16
Y1 - 1997/5/16
N2 - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).
AB - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).
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U2 - 10.1016/S0304-3940(97)00324-8
DO - 10.1016/S0304-3940(97)00324-8
M3 - Article
C2 - 9180214
AN - SCOPUS:0030985958
VL - 227
SP - 103
EP - 106
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -