Decreased Skeletal Muscle Vasodilation in Patients with Congestive Heart Failure

Tsutomu Imaizumi, Yoshitake Hirooka, Akira Takeshita, Tsutomu Imaizumi

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    In congestive heart failure (CHF), excessive vasoconstriction is present, which is due to overactive vasoconstrictor mechanisms although vasodilator mechanisms may be impaired. In the present study, we examined vasodilation in CHF by measuring forearm blood flow with a strain gauge plethysmograph. Patients with CHF had higher forearm vascular resistance than normal control subjects. Patients with CHF had decreased forearm vasodilation in response to intra-arterial infusions of atrial natriuretic peptide (ANP) and acetylcholine, but not in response to sodium nitroprusside or nitroglycerin. Oral captopril did not alter the degree of forearm vasodilation during handgrip exercise. These results suggest that endothelium-dependent and ANP-induced forearm vasodilation is impaired in patients with CHF but the decreased vasodilation is not due to impaired vascular smooth muscle responsiveness to a vasodilator. The renin-angiotensin system does not seem to play a major role in the maintenance of vascular resistance during exercise in CHF.

    Original languageEnglish
    Pages (from-to)500-503
    Number of pages4
    Issue number5
    Publication statusPublished - 1992

    All Science Journal Classification (ASJC) codes

    • Physiology
    • Cardiology and Cardiovascular Medicine


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