Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia

Choji Obayashi, Taisuke Nakashima, Toshiaki Onitsuka, Toshihiko Maekawa, Yoji Hirano, Shogo Hirano, Naoya Oribe, Kunihiko Kaneko, Shigenobu Kanba, Shozo Tobimatsu

Research output: Contribution to journalArticle

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Abstract

Objective: Schizophrenia impairs early visual cognitive processing. Low and high spatial frequency (LSF, HSF) visual information are differentially processed in humans. We investigated whether electrophysiological abnormalities exist in visual processing for spatial frequency (SF)-filtered neutral/emotional faces in schizophrenics. Methods: Subjects consisted of 16 male chronic schizophrenics and 23 controls. Event-related potentials (ERPs) to SF-filtered (LSF or HSF) and unfiltered (broad SF; BSF) pictures of neutral, happy, and fearful faces were recorded at 20 scalp sites. The relationships between the P100 (P1)/N170 amplitudes and the Global Assessment of Functioning (GAF) scores in patients were also evaluated. Results: For the P1 amplitudes at O1/O2, controls exhibited a significant LSF > BSF difference, while schizophrenics showed no LSF > BSF difference. For the N170 amplitudes at T5/T6, controls revealed a significant HSF > BSF difference, while schizophrenics showed no such difference. For the P1 latencies, controls but not schizophrenics showed a significant difference (LSF > BSF = HSF). For the N170 latencies, no significant SF differentiation was found between the two groups. For both P1 and N170 amplitudes, no significant effects of facial expressions were observed in controls and patients regardless of SFs. There were significant negative correlations between the GAF scores and the N170 amplitudes to BSF faces in schizophrenics, but not for P1 amplitudes. Conclusions: Schizophrenics showed abnormal P1 and N170 responses to SF changes in faces, thus indicating decreased SF sensitivities for processing of faces. Significance: Abnormal early visual processing may underlie some of the deficits associated with face recognition in schizophrenia.

Original languageEnglish
Pages (from-to)1525-1533
Number of pages9
JournalClinical Neurophysiology
Volume120
Issue number8
DOIs
Publication statusPublished - Aug 1 2009

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Schizophrenia
Facial Expression
Scalp
Evoked Potentials

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia. / Obayashi, Choji; Nakashima, Taisuke; Onitsuka, Toshiaki; Maekawa, Toshihiko; Hirano, Yoji; Hirano, Shogo; Oribe, Naoya; Kaneko, Kunihiko; Kanba, Shigenobu; Tobimatsu, Shozo.

In: Clinical Neurophysiology, Vol. 120, No. 8, 01.08.2009, p. 1525-1533.

Research output: Contribution to journalArticle

Obayashi, Choji ; Nakashima, Taisuke ; Onitsuka, Toshiaki ; Maekawa, Toshihiko ; Hirano, Yoji ; Hirano, Shogo ; Oribe, Naoya ; Kaneko, Kunihiko ; Kanba, Shigenobu ; Tobimatsu, Shozo. / Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia. In: Clinical Neurophysiology. 2009 ; Vol. 120, No. 8. pp. 1525-1533.
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abstract = "Objective: Schizophrenia impairs early visual cognitive processing. Low and high spatial frequency (LSF, HSF) visual information are differentially processed in humans. We investigated whether electrophysiological abnormalities exist in visual processing for spatial frequency (SF)-filtered neutral/emotional faces in schizophrenics. Methods: Subjects consisted of 16 male chronic schizophrenics and 23 controls. Event-related potentials (ERPs) to SF-filtered (LSF or HSF) and unfiltered (broad SF; BSF) pictures of neutral, happy, and fearful faces were recorded at 20 scalp sites. The relationships between the P100 (P1)/N170 amplitudes and the Global Assessment of Functioning (GAF) scores in patients were also evaluated. Results: For the P1 amplitudes at O1/O2, controls exhibited a significant LSF > BSF difference, while schizophrenics showed no LSF > BSF difference. For the N170 amplitudes at T5/T6, controls revealed a significant HSF > BSF difference, while schizophrenics showed no such difference. For the P1 latencies, controls but not schizophrenics showed a significant difference (LSF > BSF = HSF). For the N170 latencies, no significant SF differentiation was found between the two groups. For both P1 and N170 amplitudes, no significant effects of facial expressions were observed in controls and patients regardless of SFs. There were significant negative correlations between the GAF scores and the N170 amplitudes to BSF faces in schizophrenics, but not for P1 amplitudes. Conclusions: Schizophrenics showed abnormal P1 and N170 responses to SF changes in faces, thus indicating decreased SF sensitivities for processing of faces. Significance: Abnormal early visual processing may underlie some of the deficits associated with face recognition in schizophrenia.",
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AU - Hirano, Yoji

AU - Hirano, Shogo

AU - Oribe, Naoya

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AB - Objective: Schizophrenia impairs early visual cognitive processing. Low and high spatial frequency (LSF, HSF) visual information are differentially processed in humans. We investigated whether electrophysiological abnormalities exist in visual processing for spatial frequency (SF)-filtered neutral/emotional faces in schizophrenics. Methods: Subjects consisted of 16 male chronic schizophrenics and 23 controls. Event-related potentials (ERPs) to SF-filtered (LSF or HSF) and unfiltered (broad SF; BSF) pictures of neutral, happy, and fearful faces were recorded at 20 scalp sites. The relationships between the P100 (P1)/N170 amplitudes and the Global Assessment of Functioning (GAF) scores in patients were also evaluated. Results: For the P1 amplitudes at O1/O2, controls exhibited a significant LSF > BSF difference, while schizophrenics showed no LSF > BSF difference. For the N170 amplitudes at T5/T6, controls revealed a significant HSF > BSF difference, while schizophrenics showed no such difference. For the P1 latencies, controls but not schizophrenics showed a significant difference (LSF > BSF = HSF). For the N170 latencies, no significant SF differentiation was found between the two groups. For both P1 and N170 amplitudes, no significant effects of facial expressions were observed in controls and patients regardless of SFs. There were significant negative correlations between the GAF scores and the N170 amplitudes to BSF faces in schizophrenics, but not for P1 amplitudes. Conclusions: Schizophrenics showed abnormal P1 and N170 responses to SF changes in faces, thus indicating decreased SF sensitivities for processing of faces. Significance: Abnormal early visual processing may underlie some of the deficits associated with face recognition in schizophrenia.

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