Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment: An fMRI study

Takao Yamasaki, Toshihiko Aso, Yumiko Kaseda, Yasuyo Mimori, Hikaru Doi, Naoki Matsuoka, Naomi Takamiya, Tsuyoshi Torii, Tetsuya Takahashi, Tomohiko Ohshita, Hiroshi Yamashita, Hitoka Doi, Saeko Inamizu, Hiroshi Chatani, Shozo Tobimatsu

Research output: Contribution to journalArticlepeer-review

Abstract

Motion perceptual deficits are common in Alzheimer's disease (AD). Although the posterior parietal cortex is thought to play a critical role in these deficits, it is currently unclear whether the primary visual cortex (V1) contributes to these deficits in AD. To elucidate this issue, we investigated the net activity or connectivity within V1 in 17 amnestic mild cognitive impairment (aMCI) patients, 17 AD patients and 17 normal controls (NC) using functional magnetic resonance imaging (fMRI). fMRI was recorded under two conditions: visual motion stimulation and resting-state. The net activity or connectivity within V1 extracted by independent component analysis (ICA) was significantly increased during visual motion stimuli compared with that of the resting-state condition in NC, but not in aMCI or AD patients. These findings suggest the alteration of the net activity or connectivity within V1, which may contribute to the previously reported motion perceptual deficits in aMCI and AD. Therefore, the decreased net V1 activity measured as the strength of the ICA component may provide a new disease biomarker for early detection of AD.

Original languageEnglish
Article number134402
JournalNeuroscience Letters
Volume711
DOIs
Publication statusPublished - Oct 15 2019

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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