Decreased thalamic metabolism without thalamic magnetic resonance imaging abnormalities following shearing injury to the substantia nigra

Akira Nakamizo, Takanori Inamura, Toshiyuki Amano, Satoshi Inoha, Kentaro Tokuda, Osamu Yasuda, Kiyonobu Ikezaki, Masashi Fukui

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A 36-year-old man had fallen about 8 metres. Radiographs showed a mandibular fracture, indicating rotatory force applied to the head. Fluid-attenuated inversion recovery (FLAIR) imaging showed hyperintensity in both medial temporal lobes, left medial midbrain, right midbrain including cerebral peduncle, left pulvinar, left external capsule, fornix, splenium of corpus callosum, and deep white matter of both frontal lobes. Quantitative [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) indicated markedly suppressed glucose metabolism in the left thalamus but not markedly in the striatum. At that time the neurologic examination demonstrated complete left hemiparesis, severe rigidity of the right upper extremity, and inability to move the right hand and fingers. Levodopa at 300-600mg/day improved movement of the fingers, decreased the rigidity in the extremity, and lessened the metabolic abnormality. Diminished metabolism in the left thalamus may have contributed to symptoms. The case illustrates the usefulness of PET in disclosing symptom causing abnormalities not detected by magnetic resonance imaging.

Original languageEnglish
Pages (from-to)685-688
Number of pages4
JournalJournal of Clinical Neuroscience
Volume9
Issue number6
DOIs
Publication statusPublished - Jan 1 2002

Fingerprint

Substantia Nigra
Mesencephalon
Thalamus
Positron-Emission Tomography
Fingers
Magnetic Resonance Imaging
Pulvinar
Mandibular Fractures
Corpus Callosum
Fluorodeoxyglucose F18
Wounds and Injuries
Neurologic Examination
Levodopa
Frontal Lobe
Paresis
Temporal Lobe
Upper Extremity
Extremities
Hand
Head

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Decreased thalamic metabolism without thalamic magnetic resonance imaging abnormalities following shearing injury to the substantia nigra. / Nakamizo, Akira; Inamura, Takanori; Amano, Toshiyuki; Inoha, Satoshi; Tokuda, Kentaro; Yasuda, Osamu; Ikezaki, Kiyonobu; Fukui, Masashi.

In: Journal of Clinical Neuroscience, Vol. 9, No. 6, 01.01.2002, p. 685-688.

Research output: Contribution to journalArticle

Nakamizo, Akira ; Inamura, Takanori ; Amano, Toshiyuki ; Inoha, Satoshi ; Tokuda, Kentaro ; Yasuda, Osamu ; Ikezaki, Kiyonobu ; Fukui, Masashi. / Decreased thalamic metabolism without thalamic magnetic resonance imaging abnormalities following shearing injury to the substantia nigra. In: Journal of Clinical Neuroscience. 2002 ; Vol. 9, No. 6. pp. 685-688.
@article{7713bb243a36421e94a9eccda266a8ea,
title = "Decreased thalamic metabolism without thalamic magnetic resonance imaging abnormalities following shearing injury to the substantia nigra",
abstract = "A 36-year-old man had fallen about 8 metres. Radiographs showed a mandibular fracture, indicating rotatory force applied to the head. Fluid-attenuated inversion recovery (FLAIR) imaging showed hyperintensity in both medial temporal lobes, left medial midbrain, right midbrain including cerebral peduncle, left pulvinar, left external capsule, fornix, splenium of corpus callosum, and deep white matter of both frontal lobes. Quantitative [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) indicated markedly suppressed glucose metabolism in the left thalamus but not markedly in the striatum. At that time the neurologic examination demonstrated complete left hemiparesis, severe rigidity of the right upper extremity, and inability to move the right hand and fingers. Levodopa at 300-600mg/day improved movement of the fingers, decreased the rigidity in the extremity, and lessened the metabolic abnormality. Diminished metabolism in the left thalamus may have contributed to symptoms. The case illustrates the usefulness of PET in disclosing symptom causing abnormalities not detected by magnetic resonance imaging.",
author = "Akira Nakamizo and Takanori Inamura and Toshiyuki Amano and Satoshi Inoha and Kentaro Tokuda and Osamu Yasuda and Kiyonobu Ikezaki and Masashi Fukui",
year = "2002",
month = "1",
day = "1",
doi = "10.1054/jocn.2002.1146",
language = "English",
volume = "9",
pages = "685--688",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "6",

}

TY - JOUR

T1 - Decreased thalamic metabolism without thalamic magnetic resonance imaging abnormalities following shearing injury to the substantia nigra

AU - Nakamizo, Akira

AU - Inamura, Takanori

AU - Amano, Toshiyuki

AU - Inoha, Satoshi

AU - Tokuda, Kentaro

AU - Yasuda, Osamu

AU - Ikezaki, Kiyonobu

AU - Fukui, Masashi

PY - 2002/1/1

Y1 - 2002/1/1

N2 - A 36-year-old man had fallen about 8 metres. Radiographs showed a mandibular fracture, indicating rotatory force applied to the head. Fluid-attenuated inversion recovery (FLAIR) imaging showed hyperintensity in both medial temporal lobes, left medial midbrain, right midbrain including cerebral peduncle, left pulvinar, left external capsule, fornix, splenium of corpus callosum, and deep white matter of both frontal lobes. Quantitative [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) indicated markedly suppressed glucose metabolism in the left thalamus but not markedly in the striatum. At that time the neurologic examination demonstrated complete left hemiparesis, severe rigidity of the right upper extremity, and inability to move the right hand and fingers. Levodopa at 300-600mg/day improved movement of the fingers, decreased the rigidity in the extremity, and lessened the metabolic abnormality. Diminished metabolism in the left thalamus may have contributed to symptoms. The case illustrates the usefulness of PET in disclosing symptom causing abnormalities not detected by magnetic resonance imaging.

AB - A 36-year-old man had fallen about 8 metres. Radiographs showed a mandibular fracture, indicating rotatory force applied to the head. Fluid-attenuated inversion recovery (FLAIR) imaging showed hyperintensity in both medial temporal lobes, left medial midbrain, right midbrain including cerebral peduncle, left pulvinar, left external capsule, fornix, splenium of corpus callosum, and deep white matter of both frontal lobes. Quantitative [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) indicated markedly suppressed glucose metabolism in the left thalamus but not markedly in the striatum. At that time the neurologic examination demonstrated complete left hemiparesis, severe rigidity of the right upper extremity, and inability to move the right hand and fingers. Levodopa at 300-600mg/day improved movement of the fingers, decreased the rigidity in the extremity, and lessened the metabolic abnormality. Diminished metabolism in the left thalamus may have contributed to symptoms. The case illustrates the usefulness of PET in disclosing symptom causing abnormalities not detected by magnetic resonance imaging.

UR - http://www.scopus.com/inward/record.url?scp=0036852661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036852661&partnerID=8YFLogxK

U2 - 10.1054/jocn.2002.1146

DO - 10.1054/jocn.2002.1146

M3 - Article

VL - 9

SP - 685

EP - 688

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

IS - 6

ER -