Decreased tissue accumulation of 6-deoxy-6-[18F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate

Fumihiko Yamamoto, Tetsuo Kaneshiro, Hiroharu Kato, Takahiro Mukai, Yasuo Kuwabara, Hiroshi Honda, Minoru Maeda

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    6 Citations (Scopus)

    Abstract

    The relationship between in vivo biodistribution of 6-deoxy-6-[ 18F]fluoro-L-ascorbic acid (18F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of 18F-DFA, the accumulation of radioactivity in most tissues, including the adrenal glands, liver and brain, was significantly reduced together with a decrease in the content of GSH by preloading of diethyl maleate (DEM) which depletes cellular GSH. Similar decreased uptake was also observed in the distribution of L-[1- 14C]ascorbic acid (14C-AA) after DEM treatment. The possible biological mechanisms, including competition with endogenous AA and ascorbate recycling, that modulate the uptake and accumulation into tissues of 18F-DFA and 14C-AA in GSH-deficient rats are discussed.

    Original languageEnglish
    Pages (from-to)1943-1947
    Number of pages5
    JournalBiological and Pharmaceutical Bulletin
    Volume28
    Issue number10
    DOIs
    Publication statusPublished - Oct 1 2005

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmaceutical Science

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