Decreased tissue accumulation of 6-deoxy-6-[18F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate

Fumihiko Yamamoto; Tetsuo Kaneshiro; Hiroharu Kato; Takahiro Mukai; Yasuo Kuwabara; Hiroshi Honda; Minoru Maeda

doi:10.1248/bpb.28.1943

Decreased tissue accumulation of 6-deoxy-6-[¹⁸F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate

Fumihiko Yamamoto, Tetsuo Kaneshiro, Hiroharu Kato, Takahiro Mukai, Yasuo Kuwabara, Hiroshi Honda, Minoru Maeda

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

The relationship between in vivo biodistribution of 6-deoxy-6-[ ¹⁸F]fluoro-L-ascorbic acid (¹⁸F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of ¹⁸F-DFA, the accumulation of radioactivity in most tissues, including the adrenal glands, liver and brain, was significantly reduced together with a decrease in the content of GSH by preloading of diethyl maleate (DEM) which depletes cellular GSH. Similar decreased uptake was also observed in the distribution of L-[1- ¹⁴C]ascorbic acid (¹⁴C-AA) after DEM treatment. The possible biological mechanisms, including competition with endogenous AA and ascorbate recycling, that modulate the uptake and accumulation into tissues of ¹⁸F-DFA and ¹⁴C-AA in GSH-deficient rats are discussed.

Original language	English
Pages (from-to)	1943-1947
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	28
Issue number	10
DOIs	https://doi.org/10.1248/bpb.28.1943
Publication status	Published - Oct 1 2005

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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10.1248/bpb.28.1943

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Yamamoto, F., Kaneshiro, T., Kato, H., Mukai, T., Kuwabara, Y., Honda, H., & Maeda, M. (2005). Decreased tissue accumulation of 6-deoxy-6-[¹⁸F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate. Biological and Pharmaceutical Bulletin, 28(10), 1943-1947. https://doi.org/10.1248/bpb.28.1943

Decreased tissue accumulation of 6-deoxy-6-[¹⁸F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate. / Yamamoto, Fumihiko; Kaneshiro, Tetsuo; Kato, Hiroharu; Mukai, Takahiro; Kuwabara, Yasuo; Honda, Hiroshi; Maeda, Minoru.

In: Biological and Pharmaceutical Bulletin, Vol. 28, No. 10, 01.10.2005, p. 1943-1947.

Research output: Contribution to journal › Article

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abstract = "The relationship between in vivo biodistribution of 6-deoxy-6-[ 18F]fluoro-L-ascorbic acid (18F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of 18F-DFA, the accumulation of radioactivity in most tissues, including the adrenal glands, liver and brain, was significantly reduced together with a decrease in the content of GSH by preloading of diethyl maleate (DEM) which depletes cellular GSH. Similar decreased uptake was also observed in the distribution of L-[1- 14C]ascorbic acid (14C-AA) after DEM treatment. The possible biological mechanisms, including competition with endogenous AA and ascorbate recycling, that modulate the uptake and accumulation into tissues of 18F-DFA and 14C-AA in GSH-deficient rats are discussed.",

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