Decreased tissue accumulation of 6-deoxy-6-[18F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate

Fumihiko Yamamoto, Tetsuo Kaneshiro, Hiroharu Kato, Takahiro Mukai, Yasuo Kuwabara, Hiroshi Honda, Minoru Maeda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The relationship between in vivo biodistribution of 6-deoxy-6-[ 18F]fluoro-L-ascorbic acid (18F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of 18F-DFA, the accumulation of radioactivity in most tissues, including the adrenal glands, liver and brain, was significantly reduced together with a decrease in the content of GSH by preloading of diethyl maleate (DEM) which depletes cellular GSH. Similar decreased uptake was also observed in the distribution of L-[1- 14C]ascorbic acid (14C-AA) after DEM treatment. The possible biological mechanisms, including competition with endogenous AA and ascorbate recycling, that modulate the uptake and accumulation into tissues of 18F-DFA and 14C-AA in GSH-deficient rats are discussed.

Original languageEnglish
Pages (from-to)1943-1947
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 1 2005

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diethyl maleate
Glutathione
Ascorbic Acid
Recycling
Adrenal Glands
Intravenous Administration
Radioactivity
Wistar Rats
Liver
Brain
6-deoxy-6-fluoroascorbic acid

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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Decreased tissue accumulation of 6-deoxy-6-[18F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate. / Yamamoto, Fumihiko; Kaneshiro, Tetsuo; Kato, Hiroharu; Mukai, Takahiro; Kuwabara, Yasuo; Honda, Hiroshi; Maeda, Minoru.

In: Biological and Pharmaceutical Bulletin, Vol. 28, No. 10, 01.10.2005, p. 1943-1947.

Research output: Contribution to journalArticle

Yamamoto, Fumihiko ; Kaneshiro, Tetsuo ; Kato, Hiroharu ; Mukai, Takahiro ; Kuwabara, Yasuo ; Honda, Hiroshi ; Maeda, Minoru. / Decreased tissue accumulation of 6-deoxy-6-[18F]fluoro-L- ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate. In: Biological and Pharmaceutical Bulletin. 2005 ; Vol. 28, No. 10. pp. 1943-1947.
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AU - Honda, Hiroshi

AU - Maeda, Minoru

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