Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report

Akio Sakamoto, Hidetaka Yamamoto, Kazuhiro Tanaka, Shuichi Matsuda, Katsumi Harimaya, Yoshinao Oda, Masazumi Tsuneyoshi, Yukihide Iwamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytomaor osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. Conclusion: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.

Original languageEnglish
Article number37
JournalWorld Journal of Surgical Oncology
Volume4
DOIs
Publication statusPublished - Jul 4 2006

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Chondrosarcoma
Leukocytosis
Granulocyte Colony-Stimulating Factor
Serum
Neoplasms
Hemipelvectomy
Pelvic Bones
Neoplasm Metastasis
Recurrence
Multiple Organ Failure
Osteosarcoma
Autopsy
Intercellular Signaling Peptides and Proteins
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report. / Sakamoto, Akio; Yamamoto, Hidetaka; Tanaka, Kazuhiro; Matsuda, Shuichi; Harimaya, Katsumi; Oda, Yoshinao; Tsuneyoshi, Masazumi; Iwamoto, Yukihide.

In: World Journal of Surgical Oncology, Vol. 4, 37, 04.07.2006.

Research output: Contribution to journalArticle

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AU - Sakamoto, Akio

AU - Yamamoto, Hidetaka

AU - Tanaka, Kazuhiro

AU - Matsuda, Shuichi

AU - Harimaya, Katsumi

AU - Oda, Yoshinao

AU - Tsuneyoshi, Masazumi

AU - Iwamoto, Yukihide

PY - 2006/7/4

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N2 - Background: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytomaor osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. Conclusion: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.

AB - Background: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytomaor osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. Conclusion: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.

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