Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry

Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Yuji Komorita, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Constipation has been shown to be associated with a higher risk of diabetes. However, few studies have evaluated the relationship between defecation frequency, one of the major symptoms of constipation, and glycemic control in patients with diabetes. The aim of the present study was to determine the relationship between defecation frequency and HbA1c in patients with diabetes. Methods: We determined the relationship between defecation frequency and HbA1c in 5029 patients with diabetes in the Fukuoka Diabetes Registry, a multi-center prospective cohort study conducted in diabetes specialist outpatient clinic (mean age 64.9 years, men 55%). Participants were classified according to their defecation frequency: ≥7, 3–<7 and <3 times/week. Results: Low defecation frequency was linearly associated with high HbA1c, with mean levels of 7.41% (95% confidence interval, 7.37–7.44%), 7.54% (7.49–7.60%) and 7.63% (7.52–7.74%) for patients with defecation frequencies of ≥7 times/week, 3–<7 times/week and <3 times/week (p for trend <0.001). This association remained after multivariable adjustment for confounding factors. There was no evidence of heterogeneity in the association between defecation frequency and HbA1c level according to age, sex, type of diabetes, or laxative use. Conclusions: The present study suggests the importance of assessing defecation frequency in the management of diabetes.

Original languageEnglish
Article number107751
JournalJournal of Diabetes and Its Complications
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry'. Together they form a unique fingerprint.

Cite this