Defects in homologous recombination repair behind the human diseases: FA and HBOC

Yoko Katsuki, Minoru Takata

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Hereditary breast and ovarian cancer (HBOC) syndrome and a rare childhood disorder Fanconi anemia (FA) are caused by homologous recombination (HR) defects, and some of the causative genes overlap. Recent studies in this field have led to the exciting development of PARP inhibitors as novel cancer therapeutics and have clarified important mechanisms underlying genome instability and tumor suppression in HR-defective disorders. In this review, we provide an overview of the basic molecular mechanisms governing HR and DNA crosslink repair, highlighting BRCA2, and the intriguing relationship between HBOC and FA.

Original languageEnglish
Pages (from-to)T19-T37
JournalEndocrine-Related Cancer
Volume23
Issue number10
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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