TY - JOUR
T1 - Degas-Driven Deterministic Lateral Displacement in Poly(dimethylsiloxane) Microfluidic Devices
AU - Tottori, Naotomo
AU - Nisisako, Takasi
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant No. 17J10441.
Publisher Copyright:
© 2019 American Chemical Society.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/2/19
Y1 - 2019/2/19
N2 - In this work, degas-driven microfluidic deterministic lateral displacement devices were fabricated from poly(dimethylsiloxane). Two device configurations were considered: One with a single input for the enrichment of particles and the other one with sheath inputs for the separation of particles based on their sizes. Using the single-input device, the characteristics of the degas-driven fluid through micropillars were investigated, and then selective enrichment of fluorescent polymer particles with diameters of around 13 μm mixed with similar 7 μm particles was demonstrated. Using the sheath-input device, the separation of 13 and 7 μm beads was achieved (the corresponding purities exceeded 92.62% and 99.98%, respectively). In addition, clusters composed of 7 μm beads (including doublets, triplets, and quadruplets) were fractionated based on their equivalent sizes. Finally, white blood cells could be separated from red blood cells at a relatively high capture efficiency (95.57%) and purity (86.97%).
AB - In this work, degas-driven microfluidic deterministic lateral displacement devices were fabricated from poly(dimethylsiloxane). Two device configurations were considered: One with a single input for the enrichment of particles and the other one with sheath inputs for the separation of particles based on their sizes. Using the single-input device, the characteristics of the degas-driven fluid through micropillars were investigated, and then selective enrichment of fluorescent polymer particles with diameters of around 13 μm mixed with similar 7 μm particles was demonstrated. Using the sheath-input device, the separation of 13 and 7 μm beads was achieved (the corresponding purities exceeded 92.62% and 99.98%, respectively). In addition, clusters composed of 7 μm beads (including doublets, triplets, and quadruplets) were fractionated based on their equivalent sizes. Finally, white blood cells could be separated from red blood cells at a relatively high capture efficiency (95.57%) and purity (86.97%).
UR - http://www.scopus.com/inward/record.url?scp=85061473790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061473790&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.8b05587
DO - 10.1021/acs.analchem.8b05587
M3 - Article
C2 - 30672690
AN - SCOPUS:85061473790
SN - 0003-2700
VL - 91
SP - 3093
EP - 3100
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 4
ER -